2-Deoxy-D-glucose

• Catalog No.: D3179
• CAS Number: 154-17-6
• M. F.: C6H12O5
• M. W.: 164.15648
• Purity: ≥98%

SYNONYMS

• Title: D-2-脱氧葡萄糖
• IUPAC name: (3R,4S,5R)-3,4,5,6-tetrahydroxyhexanal
• IUPAC Traditional name: deoxyglucose
• Synonyms: 2-脱氧-D-葡糖

DATABASE IDS

• PubChem SID: 24893732
• CAS Number: 154-17-6
• MDL Number: MFCD00151328
• EC Number: 205-823-0
• Beilstein Number: 1723331

PROPERTIES

• Antion Traces: chloride (Cl-): ≤0.05%
• Antion Traces: sulfate (SO42-): ≤0.05%
• Cation Traces: Al: ≤0.0005%
• Cation Traces: Ca: ≤0.003%
• Cation Traces: Cu: ≤0.0005%
• Cation Traces: Fe: ≤0.0005%
• Cation Traces: K: ≤0.005%
• Cation Traces: Mg: ≤0.0005%
• Cation Traces: NH4+: ≤0.05%
• Cation Traces: Na: ≤0.005%
• Cation Traces: Pb: ≤0.001%
• Cation Traces: Zn: ≤0.0005%
• Ignition Residue: <0.1%
• Impurities: ≤0.001% Phosphorus (P)
• Impurities: <0.1% Insoluble matter
• Purity: ≥98%
• Melting Point: 146-147 °C(lit.)
• Solubility: H2O: soluble1 M at 20 °C, clear, colorless
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• German water hazard class: 3

DETAILS

Description (English)

Application
2-Deoxy-D-glucose is used in the development of anti-cancer strategies that involve radio- and chemosensitization and oxidative stress.
Biochem/physiol Actions
2-Deoxy-D-Glucose (2-Deoxyglucose) is a glucose analog that inhibits glycolysis via its actions on hexokinase, the rate limiting step of glycolysis. It is phosphorylated by hexokinase to 2-DG-P which can not be further metabolized by phosphoglucose isomerase. This leads to the accumulation of 2-DG-P in the cell and the depletion in cellular ATP. In vitro, 2-Deoxyglucose has been shown to induce autophagy, increase ROS production, and activate AMPK.1