6-Thioguanine

• Catalog No.: A4882
• CAS Number: 154-42-7
• M. F.: C5H5N5S
• M. W.: 167.1917
• Purity: ≥98%

SYNONYMS

• Title: 6-硫鸟嘌呤
• IUPAC name: 2-amino-6,7-dihydro-1H-purine-6-thione
• IUPAC Traditional name: 2-aminopurine-6(1h)-thione
• Synonyms: 2-氨基-6-巯嘌呤; 2-氨基-6巯基嘌呤

DATABASE IDS

• CAS Number: 154-42-7
• Beilstein Number: 157765
• PubChem SID: 24890748
• MDL Number: MFCD00233553
• EC Number: 205-827-2

PROPERTIES

• Purity: ≥98%
• Melting Point: ≥300 °C(lit.)

DETAILS

Description (简体中文)

Biochem/physiol Actions
Antimetabolite used in the treatment of leukemias. Competes with hypoxanthine and guanine for the enzyme hypoxanthine-guanine phosphoribosyltransferase, which catalzyes a critical step in the generation of purine nucleotides.
Ribosylated and phosphorylated by the same pathway as natural purine bases; as the nucleotide, inhibits a variety of cellular processes involved in nucleic acid synthesis. Has a long history as an effective treatment of leukemia.1
包装
1, 5 g in glass bottle
100, 250, 500 mg in glass bottle