Rifampicin

• Catalog No.: R3501
• CAS Number: 13292-46-1
• M. F.: C43H58N4O12
• M. W.: 822.94022
• Purity: ≥97% (HPLC)

SYNONYMS

• Title: 利福平
• IUPAC name: (7S,9Z,11S,12R,13S,14R,15R,16R,17S,18S,19Z,21Z)-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-26-[(E)-N-(4-methylpiperazin-1-yl)carboximidoyl]-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.1^4,^7.0^5,^2^8]triaconta-1(29),2,4,9,19,21,25,27-octaen-13-yl acetate
• IUPAC Traditional name: (7S,9Z,11S,12R,13S,14R,15R,16R,17S,18S,19Z,21Z)-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-26-[(E)-N-(4-methylpiperazin-1-yl)carboximidoyl]-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.1^4,^7.0^5,^2^8]triaconta-1(29),2,4,9,19,21,25,27-octaen-13-yl acetate
• Synonyms: 利米定; 甲哌利福霉素; 3-(4-甲基-1-哌嗪基亚胺甲基)利福霉素SV

DATABASE IDS

• PubChem SID: 24899363
• EC Number: 236-312-0
• CAS Number: 13292-46-1
• Beilstein Number: 5723476
• MDL Number: MFCD00151389

PROPERTIES

• Purity: ≥97% (HPLC)
• Apperance: faint-orange to red-brown powder
• Solubility: H2O: soluble1.3 mg/mL (pH 4.3)
• Solubility: DMSO: soluble100 mg/mL
• Solubility: H2O: soluble2.5 mg/mL at 25 °C (pH 7.3)
• GHS Signal Word: Warning
• GHS Hazard statements: H302-H315-H319-H335
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P261-P305 + P351 + P338
• Risk Statements: 22-36/37/38
• RTECS: VJ7000000
• Safety Statements: 26-36
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (English)

Frequently Asked Questions
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Biochem/physiol Actions
Inhibits the assembly of DNA and protein into mature virus particles.
Mode of Action: Inhibits initiation of RNA synthesis by binding to β-subunit of RNA polymerase.
Rifampicin inhibits the assembly of DNA and protein into mature virus particles. It inhibits initiation of RNA synthesis by binding to β-subunit of RNA polymerase, which results in cell death1.
Application
Rifampicin is used to treat Tuberculosis and Tuberculosis-related mycobacterial infections1. It is widely used as an antipruritic agent in the autoimmune cholestatic liver disease, primary biliary cirrhosis (PBC). It has been shown to cause hepatitis2.
Protocols & Applications
Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information