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Rifampicin

Catalog No. R3501 Name Sigma Aldrich
CAS Number 13292-46-1 Website http://www.sigmaaldrich.com
M. F. C43H58N4O12 Telephone 1-800-521-8956
M. W. 822.94022 Fax
Purity ≥97% (HPLC) Email
Storage Chembase ID: 134128

SYNONYMS

Title
利福平
IUPAC name
(7S,9Z,11S,12R,13S,14R,15R,16R,17S,18S,19Z,21Z)-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-26-[(E)-N-(4-methylpiperazin-1-yl)carboximidoyl]-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.14,7.05,28]triaconta-1(29),2,4,9,19,21,25,27-octaen-13-yl acetate
IUPAC Traditional name
(7S,9Z,11S,12R,13S,14R,15R,16R,17S,18S,19Z,21Z)-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-26-[(E)-N-(4-methylpiperazin-1-yl)carboximidoyl]-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.14,7.05,28]triaconta-1(29),2,4,9,19,21,25,27-octaen-13-yl acetate
Synonyms
利米定
甲哌利福霉素
3-(4-甲基-1-哌嗪基亚胺甲基)利福霉素SV

DATABASE IDS

PubChem SID 24899363
EC Number 236-312-0
CAS Number 13292-46-1
Beilstein Number 5723476
MDL Number MFCD00151389

PROPERTIES

Purity ≥97% (HPLC)
Apperance faint-orange to red-brown powder
Solubility H2O: soluble1.3 mg/mL (pH 4.3)
Solubility DMSO: soluble100 mg/mL
Solubility H2O: soluble2.5 mg/mL at 25 °C (pH 7.3)
GHS Pictograms GHS07
GHS Signal Word Warning
GHS Hazard statements H302-H315-H319-H335
European Hazard Symbols Harmful Harmful (Xn)
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
GHS Precautionary statements P261-P305 + P351 + P338
Risk Statements 22-36/37/38
RTECS VJ7000000
Safety Statements 26-36
Storage Temperature -20°C
German water hazard class 3

DETAILS

Description (English)
Frequently Asked Questions
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Biochem/physiol Actions
Inhibits the assembly of DNA and protein into mature virus particles.
Mode of Action: Inhibits initiation of RNA synthesis by binding to β-subunit of RNA polymerase.
Rifampicin inhibits the assembly of DNA and protein into mature virus particles. It inhibits initiation of RNA synthesis by binding to β-subunit of RNA polymerase, which results in cell death1.
Application
Rifampicin is used to treat Tuberculosis and Tuberculosis-related mycobacterial infections1. It is widely used as an antipruritic agent in the autoimmune cholestatic liver disease, primary biliary cirrhosis (PBC). It has been shown to cause hepatitis2.
Protocols & Applications
Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information

REFERENCES