Pimaricin preparation

• Catalog No.: P0440
• CAS Number: 7681-93-8
• M. F.: C33H47NO13
• M. W.: 665.72518

SYNONYMS

• Title: 游霉素 制备
• IUPAC name: (1R,3S,5R,7R,8Z,12R,14Z,16Z,18Z,20Z,22R,24S,25R,26S)-22-{[(2R,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy}-1,3,26-trihydroxy-12-methyl-10-oxo-6,11,28-trioxatricyclo[22.3.1.0^5,^7]octacosa-8,14,16,18,20-pentaene-25-carboxylic acid
• IUPAC Traditional name: (1R,3S,5R,7R,8Z,12R,14Z,16Z,18Z,20Z,22R,24S,25R,26S)-22-{[(2R,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy}-1,3,26-trihydroxy-12-methyl-10-oxo-6,11,28-trioxatricyclo[22.3.1.0^5,^7]octacosa-8,14,16,18,20-pentaene-25-carboxylic acid
• Synonyms: 那他霉素 制备

DATABASE IDS

• PubChem SID: 24898105
• CAS Number: 7681-93-8
• Beilstein Number: 1614878
• MDL Number: MFCD00135085

PROPERTIES

• Concentration: ~2.5%
• Sterility: γ-irradiated
• Apperance: aqueous suspension
• Density: 1.0 g/mL at 20 °C(lit.)
• Personal Protective Equipment: Eyeshields, Gloves
• Storage Temperature: 2-8°C
• German water hazard class: 2

DETAILS

Description (English)

Biochem/physiol Actions
An antifungal polyene macrolide that binds specifically to ergosterol and blocks fungal growth. However, unlike nysatin and filipin, pimaricin does not change the permeability of the plasma membrane.3
Application
Pimaricin is an amphoteric macrolide antifungal antibiotic from Streptomyces natalensis or S. chattanoogensis. It is used for a variety of fungal infections, mainly topically. It is used as an ergosterol and cholesterol binding agent to study lipid bilayer dynamics, especially in fungal cells. It is used to study pimaricin biosynthesis1 and as a fungicide in agar media2.