Curcumin

• Catalog No.: C1386
• CAS Number: 458-37-7
• M. F.: C21H20O6
• M. W.: 368.3799
• Purity: ~70% (HPLC)

SYNONYMS

• IUPAC name: (1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione
• IUPAC Traditional name: curcumin
• Synonyms: Natural Yellow 3; Diferuloylmethane; Diferulylmethane; (E,E)-1,7-bis(4-Hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione

DATABASE IDS

• Color Index Number: 75300
• Beilstein Number: 2306965
• MDL Number: MFCD00008365
• EC Number: 207-280-5
• CAS Number: 458-37-7
• PubChem SID: 24892408

PROPERTIES

• Biological Source: from Curcuma longa (Turmeric)
• Purity: ~70% (HPLC)
• Gene Information: human ... APP(351), CYP1A2(1544)
• Apperance: orange powder
• Solubility: ethanol: soluble10 mg/mL
• Solubility: DMSO: >11 mg/mL
• Solubility: 0.5 M NaOH: soluble (then immediately dilute in PBS)
• Vapor Density: 13 (vs air)
• GHS Signal Word: Warning
• GHS Hazard statements: H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• GHS Precautionary statements: P261-P305 + P351 + P338
• Risk Statements: 36/37/38
• RTECS: MI5230000
• Safety Statements: 26
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. Curcumin has been cited as a potential chemopreventive agent, in addition to its chemotherapeutic activity.1 Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IκB kinase. Inhibits inducible nitric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nuclear envelope.