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Curcumin

Catalog No. C1386 Name Sigma Aldrich
CAS Number 458-37-7 Website http://www.sigmaaldrich.com
M. F. C21H20O6 Telephone 1-800-521-8956
M. W. 368.3799 Fax
Purity ~70% (HPLC) Email
Storage Chembase ID: 81908

SYNONYMS

IUPAC name
(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione
IUPAC Traditional name
curcumin
Synonyms
Natural Yellow 3
Diferuloylmethane
Diferulylmethane
(E,E)-1,7-bis(4-Hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione

DATABASE IDS

Color Index Number 75300
Beilstein Number 2306965
MDL Number MFCD00008365
EC Number 207-280-5
CAS Number 458-37-7
PubChem SID 24892408

PROPERTIES

Biological Source from Curcuma longa (Turmeric)
Purity ~70% (HPLC)
Gene Information human ... APP(351), CYP1A2(1544)
Apperance orange powder
Solubility ethanol: soluble10 mg/mL
Solubility DMSO: >11 mg/mL
Solubility 0.5 M NaOH: soluble (then immediately dilute in PBS)
Vapor Density 13 (vs air)
GHS Pictograms GHS07
GHS Signal Word Warning
GHS Hazard statements H315-H319-H335
European Hazard Symbols Irritant Irritant (Xi)
GHS Precautionary statements P261-P305 + P351 + P338
Risk Statements 36/37/38
RTECS MI5230000
Safety Statements 26
Storage Temperature -20°C
German water hazard class 3

DETAILS

Description (English)
Biochem/physiol Actions
A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. Curcumin has been cited as a potential chemopreventive agent, in addition to its chemotherapeutic activity.1 Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IκB kinase. Inhibits inducible nitric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nuclear envelope.

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