UA62784

• Catalog No.: D9688
• CAS Number: 313367-92-9
• M. F.: C23H15NO3
• M. W.: 353.3701
• Purity: ≥95% (SDS-PAGE)

SYNONYMS

• IUPAC name: 4-[5-(4-methoxyphenyl)-1,3-oxazol-2-yl]-9H-fluoren-9-one
• IUPAC Traditional name: 4-[5-(4-methoxyphenyl)-1,3-oxazol-2-yl]fluoren-9-one
• Synonyms: 4-[5-(4-Methoxyphenyl)-2-oxazolyl]-9H-Fluoren-9-one

DATABASE IDS

• CAS Number: 313367-92-9
• MDL Number: MFCD00489199

PROPERTIES

• Impurities: endotoxin, tested
• Mol. Weight: glycosylated form mol wt 75-90 kDa by SDS-PAGE (reducing)
• Purity: ≥95% (SDS-PAGE)
• Recombinant: expressed in NSO cells
• Suitability: cell culture tested
• Gene Information: human ... TNFRSF10C(8794)
• Apperance: lyophilized powder
• GHS Signal Word: Warning
• GHS Hazard statements: H302
• European Hazard Symbols: Harmful (Xn)
• Risk Statements: 22
• Storage Temperature: -20°C

DETAILS

Description (English)

Analysis Note
Activity is measured by its ability to inhibit apoptosis of mouse L929 cells treated with 20 ng/mL recombinant human TRAIL or 12 ng/mL cross-linked recombinant human TRAIL.
Biochem/physiol Actions
Glycosyl-phosphatidylinositol-linked membrane protein that is a member of the TNF receptor family. Acts as a decoy receptor that inhibits TRAIL signaling.
UA62784 is a specific inhibitor of centromere protein E (CENPE) kinesin-like protein; mitotic inhibitor. CENP-E is a kinesin-like motor protein that localizes to the kinetochore during mitosis and is essential for bipolar spindle formation. UA62784 is a novel specific inhibitor of CENP-E, which likely binds within the motor domain of CENP-E. UA62784 causes reversible cell cycle arrest in mitosis before metaphase, which leads to apoptosis. The compound is not interacting with microtubules directly.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 5.0 mg bovine serum albumin.