Pimaricin

• Catalog No.: P9703
• CAS Number: 7681-93-8
• M. F.: C33H47NO13
• M. W.: 665.72518
• Purity: ≥95% (HPLC)

SYNONYMS

• Title: 游霉素
• IUPAC name: (1R,3S,5R,7R,8Z,12R,14Z,16Z,18Z,20Z,22R,24S,25R,26S)-22-{[(2R,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy}-1,3,26-trihydroxy-12-methyl-10-oxo-6,11,28-trioxatricyclo[22.3.1.0^5,^7]octacosa-8,14,16,18,20-pentaene-25-carboxylic acid
• IUPAC Traditional name: (1R,3S,5R,7R,8Z,12R,14Z,16Z,18Z,20Z,22R,24S,25R,26S)-22-{[(2R,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy}-1,3,26-trihydroxy-12-methyl-10-oxo-6,11,28-trioxatricyclo[22.3.1.0^5,^7]octacosa-8,14,16,18,20-pentaene-25-carboxylic acid
• Synonyms: 那他霉素

DATABASE IDS

• EC Number: 231-683-5
• PubChem SID: 24899055
• CAS Number: 7681-93-8
• MDL Number: MFCD00135085

PROPERTIES

• Biological Source: from Streptomyces chattanoogensis
• Purity: ≥95% (HPLC)
• Quality Level: PREMIUM
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• RTECS: TK3325000
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (简体中文)

Biochem/physiol Actions
与麦角固醇特异性结合并阻止真菌生长的抗真菌多烯大环内脂。但不同于制霉菌素和菲律宾菌素不同，那他霉素不会改变细胞质膜的渗透性3
Application
Pimaricin is an amphoteric macrolide antifungal antibiotic from Streptomyces chattanoogensis. It is used for a variety of fungal infections, mainly topically. It is used as a ergosterol and cholesterol binding agent to study lipid bilayer dynamics, especially in fungal cells. Pimaricin is used as a fungicide in agar media. It is used to study the pleitropic regulator AdpAch 1 and the gamma-butyrolactone regulatory system of Streptomyces chattanoogensis2.