(±)-DOI hydrochloride

• Catalog No.: D101
• CAS Number: 42203-78-1
• M. F.: C11H17ClINO2
• M. W.: 357.61565
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine hydrochloride
• IUPAC Traditional name: 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine hydrochloride
• Synonyms: (±)-DOI; (±)-2,5-Dimethoxy-4-iodoamphetamine hydrochloride; (±)-1-(2,5-Dimethoxy-4-iodophenyl)-2-aminopropane hydrochloride

DATABASE IDS

• PubChem SID: 24278092
• CAS Number: 42203-78-1
• MDL Number: MFCD00055199

PROPERTIES

• Purity: ≥98% (HPLC)
• Gene Information: human ... HTR2A(3356), HTR2B(3357), HTR2C(3358)
• Apperance: white to off-white solid
• Solubility: H2O: soluble10 mg/mL
• Solubility: ethanol: soluble2 mg/mL
• Drug Control: Home Office Schedule 1
• Drug Control: regulated under CDSA - not available from Sigma-Aldrich Canada
• GHS Signal Word: Warning
• GHS Hazard statements: H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P261-P305 + P351 + P338
• Risk Statements: 36/37/38
• Safety Statements: 22-26-36
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
(±)-DOI hydrochloride is a potent and selective 5-HT2 serotonin receptor agonist that crosses the blood-brain barrier, increases dopamine turnover and the treatment with DOI counteracted the expression of the nicotine-induced locomotor and neurochemical sensitization, but had no effect on nicotine-induced behavioral disinhibition. The responses to DOI provide evidence that of these receptors are abundant in the cortex, and show relatively lower levels in hippocampus and cerebellum.