Ansamitocin P-3 from Actinosynnema pretiosum

• Catalog No.: A2836
• CAS Number: 66584-72-3
• M. F.: C32H43ClN2O9
• M. W.: 635.14482
• Purity: ≥90% (HPLC)

SYNONYMS

• IUPAC name: (1S,2R,3R,5S,6S,16Z,18Z,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1^1^0,^1^4.0^3,^5]hexacosa-10,12,14(26),16,18-pentaen-6-yl 2-methylpropanoate
• IUPAC Traditional name: (1S,2R,3R,5S,6S,16Z,18Z,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1^1^0,^1^4.0^3,^5]hexacosa-10,12,14(26),16,18-pentaen-6-yl 2-methylpropanoate

DATABASE IDS

• MDL Number: MFCD00274586
• PubChem SID: 24890696
• CAS Number: 66584-72-3

PROPERTIES

• Purity: ≥90% (HPLC)
• GHS Signal Word: Warning
• GHS Hazard statements: H302-H315-H319-H332-H335
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P261-P305 + P351 + P338
• Risk Statements: 20/22-36/37/38
• RTECS: OQ2293000
• Safety Statements: 26-36
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Fungal metabolite with antineoplastic, antimitotic activity. Binds to tubulin and inhibits vinblastine-induced spiral formation.1