Phosphomycin calcium salt

• Catalog No.: P7902
• CAS Number: 26016-98-8
• M. F.: C3H5CaO4P
• M. W.: 176.121161

SYNONYMS

• Title: 磷霉素 钙盐
• IUPAC name: calcium (3-methyloxiran-2-yl)phosphonate
• IUPAC Traditional name: calcium (1R,2S)-epoxypropylphosphonate
• Synonyms: (-)-(1R,2S)-(1,2-Epoxypropyl)phosphonic acid; Fosfomycin 钙盐; Phosphonomycin

DATABASE IDS

• PubChem SID: 24898888
• EC Number: 247-408-7
• MDL Number: MFCD00070095
• CAS Number: 26016-98-8

PROPERTIES

• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• Storage Temperature: 2-8°C
• German water hazard class: 2

DETAILS

Description (English)

Application
Phosphomycin, also known as Fosfomycin, is an antibiotic produced by Streptomyces fradiae. It is used to treat uncomplicated urinary tract infections and to reduce nephrotoxicity and ototoxicity of platinum-containing anti-tumor agents. It is used to study resistance proteins in Bacillus subtilis1 and Mycobacterium tuberculosis2. It is a potential treatment for bronchiectasis3.
Biochem/physiol Actions
Fosfomycin is a phosphoenolpyruvate analog. It irreversibly inhibits enolpyruvate transferase (MurA). Therefore, the producion of N-acetylmuramic acid, an essential element of the peptidoglycan cell wall is inhibited.
Phosphomycin calcium salt blocks the formation or N-acetylmuramic acid by inhibiting UDP-Nacetylglucosamine 3-enolpyruvate transferase (MurA).