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Phosphomycin calcium salt_Molecular_structure_CAS_26016-98-8)
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Phosphomycin calcium salt

Catalog No. P7902 Name Sigma Aldrich
CAS Number 26016-98-8 Website http://www.sigmaaldrich.com
M. F. C3H5CaO4P Telephone 1-800-521-8956
M. W. 176.121161 Fax
Purity Email
Storage Chembase ID: 133975

SYNONYMS

Title
磷霉素 钙盐
IUPAC name
calcium (3-methyloxiran-2-yl)phosphonate
IUPAC Traditional name
calcium (1R,2S)-epoxypropylphosphonate
Synonyms
(-)-(1R,2S)-(1,2-Epoxypropyl)phosphonic acid
Fosfomycin 钙盐
Phosphonomycin

DATABASE IDS

PubChem SID 24898888
EC Number 247-408-7
MDL Number MFCD00070095
CAS Number 26016-98-8

PROPERTIES

Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Storage Temperature 2-8°C
German water hazard class 2

DETAILS

Description (English)
Application
Phosphomycin, also known as Fosfomycin, is an antibiotic produced by Streptomyces fradiae. It is used to treat uncomplicated urinary tract infections and to reduce nephrotoxicity and ototoxicity of platinum-containing anti-tumor agents. It is used to study resistance proteins in Bacillus subtilis1 and Mycobacterium tuberculosis2. It is a potential treatment for bronchiectasis3.
Biochem/physiol Actions
Fosfomycin is a phosphoenolpyruvate analog. It irreversibly inhibits enolpyruvate transferase (MurA). Therefore, the producion of N-acetylmuramic acid, an essential element of the peptidoglycan cell wall is inhibited.
Phosphomycin calcium salt blocks the formation or N-acetylmuramic acid by inhibiting UDP-Nacetylglucosamine 3-enolpyruvate transferase (MurA).

REFERENCES