Clozapine

• Catalog No.: C6305
• CAS Number: 5786-21-0
• M. F.: C18H19ClN4
• M. W.: 326.82326

SYNONYMS

• Title: 氯氮平
• IUPAC name: 6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatricyclo[9.4.0.0^3,^8]pentadeca-1(11),3,5,7,9,12,14-heptaene
• IUPAC Traditional name: clozapine
• Synonyms: 8-氯-11-(4-甲基-1-哌嗪基)-5H-二苯并[b,e][1,4]-二氮杂草

DATABASE IDS

• MDL Number: MFCD00153785
• CAS Number: 5786-21-0
• PubChem SID: 24277892

PROPERTIES

• Quality Level: PREMIUM
• Gene Information: human ... ADRA1A(148), ADRA2A(150), ADRA2C(152), CHRM1(1128), DRD2(1813), DRD3(1814), DRD4(1815), HRH1(3269), HRH4(59340), HTR2A(3356), HTR2C(3358), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242), HTR6(3362), HTR7(3363), KCNH1(3756), KCNH2(3757), UGT1A4(54657)rat ... Adra1a(29412), Adra2a(25083), Adrb1(24925), Chrm1(25229), Drd1a(24316), Drd2(24318), Drd3(29238), Drd4(25432), Hrh1(24448), Htr1a(24473), Htr1b(25075), Htr2a(29595), Htr2b(29581), Htr2c(25187), Htr3a(79246), Htr7(65032), Slc6a4(25553)
• Solubility: ethanol: soluble1 mg/mL
• Solubility: 0.1 M HCl: soluble30 mg/mL
• Solubility: DMSO: soluble4.8 mg/mL
• GHS Signal Word: Danger
• GHS Hazard statements: H301-H341-H361
• European Hazard Symbols: Harmful (Xn)
• GHS Precautionary statements: P281-P301 + P310
• RID/ADR: UN 2811 6.1/PG 3
• Risk Statements: 63-22-68
• Safety Statements: 36/37
• Hazard Class: 6.1
• UN Number: 2811
• Packing Group: 3
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Atypical antipsychotic compound. Selective antagonist for D4-dopamine receptor. Antagonist at 5-HT2A, 5-HT2C, 5-HT3, 5-HT6, and 5-HT7 serotonin receptors.