Clozapine

• Catalog No.: C171
• CAS Number: 5786-21-0
• M. F.: C18H19ClN4
• M. W.: 326.82326

SYNONYMS

• Title: 氯氮平
• IUPAC name: 6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatricyclo[9.4.0.0^3,^8]pentadeca-1(11),3,5,7,9,12,14-heptaene
• IUPAC Traditional name: clozapine
• Synonyms: 8-氯-11-(4-甲基-1-哌嗪基)-5H-二苯并[b,e][1,4]-二氮杂草

DATABASE IDS

• MDL Number: MFCD00153785
• CAS Number: 5786-21-0
• EC Number: 227-313-7

PROPERTIES

• Apperance: pale yellow solid
• Solubility: ethanol: soluble11 mg/mL
• Solubility: 0.1 M HCl: soluble30 mg/mL
• Solubility: DMSO: soluble4.8 mg/mL
• European Hazard Symbols: Harmful (Xn)
• RID/ADR: UN 2811 6.1/PG 3
• Risk Statements: 22-36/37/38
• RTECS: HP1750000
• Safety Statements: 26
• Hazard Class: 6.1
• UN Number: 2811
• Packing Group: 3
• German water hazard class: 3

DETAILS

Description (简体中文)

Biochem/physiol Actions
非典型抗精神病药，对 D4 多巴胺受体比对 D2 或 D3 多巴胺受体表现出更大的亲和性；在用典型抗精神病药无效的患者中，对精神分裂症的阳性和阴性症状均表现出抗精神病疗效。