N-Acetyl-Tyr-Val-Ala-Asp-7-amido-4-methylcoumarin

• Catalog No.: A2452
• CAS Number: 149231-65-2
• M. F.: C33H39N5O10
• M. W.: 665.69026
• Purity: ≥99% (TLC)

SYNONYMS

• IUPAC name: 3-(2-{2-[2-acetamido-3-(4-hydroxyphenyl)propanamido]-3-methylbutanamido}propanamido)-3-[(4-methyl-2-oxo-2H-chromen-7-yl)carbamoyl]propanoic acid
• IUPAC Traditional name: 3-(2-{2-[2-acetamido-3-(4-hydroxyphenyl)propanamido]-3-methylbutanamido}propanamido)-3-[(4-methyl-2-oxochromen-7-yl)carbamoyl]propanoic acid
• Synonyms: Ac-YVAD-AMC

DATABASE IDS

• PubChem SID: 24890658
• CAS Number: 149231-65-2
• MDL Number: MFCD00171369

PROPERTIES

• Compostion: Peptide content, ≥80%
• Purity: ≥99% (TLC)
• Gene Information: human ... CASP1(834), CASP4(837)mouse ... CASP1(12362), CASP4(12363)rat ... CASP1(25166), CASP4(114555)
• Apperance: powder
• Solubility: DMSO: soluble10 mM (The solution is stable in the dark at -20 °C for more than 1 month if no water is present.)
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (English)

Amino Acid Sequence
NAc-Tyr-Val-Ala-Asp-AMC
Caution
The lyophilized powder is stable below 0 °C for more than one year if kept dry and protected from light.
Substrates
Fluorogenic substrate for caspase 1 (Km = 14 μM) and caspase 4 (TX), cysteine proteases involved in apoptosis and inflammation.