Z-Leu-Leu-Leu-al

• Catalog No.: C2211
• CAS Number: 133407-82-6
• M. F.: C26H41N3O5
• M. W.: 475.62084
• Purity: ≥90% (HPLC)

SYNONYMS

• IUPAC name: benzyl N-[(1S)-3-methyl-1-{[(1S)-3-methyl-1-{[(2S)-4-methyl-1-oxopentan-2-yl]carbamoyl}butyl]carbamoyl}butyl]carbamate
• IUPAC Traditional name: benzyl N-[(1S)-3-methyl-1-{[(1S)-3-methyl-1-{[(2S)-4-methyl-1-oxopentan-2-yl]carbamoyl}butyl]carbamoyl}butyl]carbamate
• Synonyms: MG132

DATABASE IDS

• CAS Number: 133407-82-6
• MDL Number: MFCD00674886
• PubChem SID: 24892475

PROPERTIES

• Purity: ≥90% (HPLC)
• Quality: proteasome inhibition tested
• Gene Information: human ... CTSB(1508), NFKB1(4790), PSMA1(5682)
• Apperance: powder
• Solubility: DMSO: soluble
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (English)

Amino Acid Sequence
Z-Leu-Leu-Leu-al
Frequently Asked Questions
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Biochem/physiol Actions
Potent, membrane-permeable proteasome inhibitor. Induces neurite outgrowth in PC12 cells at 10 μM. Blocks cleavage of poly(ADP-ribose) polymerase and apoptosis in thymocytes. Proteasome inhibition induces accumulation of heat shock protein mRNA, activation of heat-shock proteins, and enhanced thermotolerance in various cell types: however, it also activates JNK-1, which initiates apoptosis in response to cell stress.