4-Chlorouracil

• Catalog No.: C9525
• CAS Number: 4270-27-3
• M. F.: C4H3ClN2O2
• M. W.: 146.53182
• Purity: ≥99%

SYNONYMS

• IUPAC name: 6-chloro-1,2,3,4-tetrahydropyrimidine-2,4-dione
• IUPAC Traditional name: 6-chloro-1,3-dihydropyrimidine-2,4-dione
• Synonyms: 6-Chlorouracil; 6-Chloro-2,4-dihydroxypyrimidine; 4-Chloro-2,6-dihydroxypyrimidine

DATABASE IDS

• CAS Number: 4270-27-3
• PubChem SID: 24893168
• EC Number: 224-258-0
• MDL Number: MFCD00014595

PROPERTIES

• Purity: ≥99%
• GHS Signal Word: Warning
• GHS Hazard statements: H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P261-P305 + P351 + P338
• Risk Statements: 36/37/38
• Safety Statements: 26-36
• German water hazard class: 3

DETAILS

Description (English)

Application
Chlorouracil (4-Chlorouracil; 6-Chlorouracil) is a halogenated uracil that is useful in studies of the effects of halogenation on nucleic acid base-pair stability and alkali metal ion affinity.Reaction of 6-chlorouracil with 4-(dimethylamino)pyridine, 4-methylpyridine, and pyridin-4-yl-morpholine yielded pyridinium-substituted uracils as chlorides which were converted into pyridinium uracilates by deprotonation. These heterocyclic mesomeric betaines are cross-conjugated and thus possess separate cationic (pyridinium) and anionic (uracilate) moieties. Calculations and X-ray single crystal analyses may be used to characterize these systems and to compare the salts with the betaines.