Domperidone

• Catalog No.: D122
• CAS Number: 57808-66-9
• M. F.: C22H24ClN5O2
• M. W.: 425.91126
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 5-chloro-1-{1-[3-(2-oxo-2,3-dihydro-1H-1,3-benzodiazol-1-yl)propyl]piperidin-4-yl}-2,3-dihydro-1H-1,3-benzodiazol-2-one
• IUPAC Traditional name: motilium
• Synonyms: 4-(5-Chloro-2-oxo-1-benzimidazolinyl)-1-[3-(2-oxobenzimidazolinyl)propyl]piperidine

DATABASE IDS

• CAS Number: 57808-66-9
• EC Number: 260-968-7
• MDL Number: MFCD00069256
• PubChem SID: 24277911

PROPERTIES

• Purity: ≥98% (HPLC)
• Gene Information: human ... DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), DRD5(1816), KCNH2(3757)rat ... Drd1a(24316), Drd2(24318), Drd3(29238), Htr3a(79246)
• Apperance: white powder
• Solubility: DMSO: >10 mg/mL
• Solubility: 0.1 M HCl: soluble
• Solubility: 0.1 M NaOH: slightly soluble
• Solubility: H2O: insoluble
• GHS Signal Word: Warning
• GHS Hazard statements: H361
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS Precautionary statements: P281
• Risk Statements: 63-62
• RTECS: DE2275900
• Safety Statements: 26-36
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Peripheral dopamine receptor antagonist that does not cross the blood-brain barrier; anti-emetic.