Ceftriaxone disodium salt hemi(heptahydrate)

• Catalog No.: C5793
• CAS Number: 104376-79-6
• M. F.: C36H46N16Na4O21S6
• M. W.: 1323.19412

SYNONYMS

• IUPAC name: disodium bis((6R,7R)-7-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido]-3-{[(2-methyl-5,6-dioxo-1-sodio-1,2,5,6-tetrahydro-1,2,4-triazin-3-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate) heptahydrate
• IUPAC Traditional name: disodium bis((6R,7R)-7-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido]-3-{[(2-methyl-5,6-dioxo-1-sodio-1,2,4-triazin-3-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate) heptahydrate

DATABASE IDS

• MDL Number: MFCD01750405
• CAS Number: 104376-79-6
• PubChem SID: 24278322
• EC Number: 277-930-0

PROPERTIES

• GHS Signal Word: Danger
• GHS Hazard statements: H315-H317-H319-H334-H335
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• GHS Precautionary statements: P261-P280-P305 + P351 + P338-P342 + P311
• Risk Statements: 36/37/38-42/43
• Safety Statements: 26-36
• Storage Temperature: 2-8°C
• German water hazard class: 1

DETAILS

Description (English)

Application
Ceftriaxone is used to study drug-induced immune hemolytic anemias 1, prophylactic strategies to reduce neonatal encephalopathy 2, pentylenetetrazole-evoked convulsions 3, the effect of expression, binding, and inhibition of PDP1 and other penicillin-binding proteins (PBPs) on bacterial cell wall mucopeptide synthesis.
Biochem/physiol Actions
Ceftriaxone is a third-generation cephalosporin antibiotic that disrupts the synthesis of the peptidoglycan layer of bacterial cell walls. It is effective against gram-positive and gram-negative bacteria. Ceftriaxone is thought to increase EAAT2 pump expression in the central nervous system and to reduce glutamatergic toxicity4.