Caffeic acid phenethyl ester

• Catalog No.: C8221
• CAS Number: 104594-70-9
• M. F.: C17H16O4
• M. W.: 284.30654
• Purity: ≥97% (HPLC)
• Storage: protect from light

SYNONYMS

• IUPAC name: 2-phenylethyl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate
• IUPAC Traditional name: caffeic acid phenethyl ester
• Synonyms: CAPE

DATABASE IDS

• MDL Number: MFCD00866470
• PubChem SID: 24278341
• CAS Number: 104594-70-9

PROPERTIES

• Purity: ≥97% (HPLC)
• Gene Information: human ... NFKB2(4791)
• Apperance: off-white powder
• Solubility: ethyl acetate: soluble50 mg/mL
• Solubility: DMSO: soluble
• Solubility: ethanol: soluble
• GHS Signal Word: Warning
• GHS Hazard statements: H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P261-P305 + P351 + P338
• Risk Statements: 36/37/38
• RTECS: UD3334375
• Safety Statements: 26-36
• Storage Condition: protect from light
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Caffeic acid phenethyl ester is a specific inhibitor of the nuclear transcription factor NF-κB.
Application
Caffeic acid phenethyl ester (CAPE) is the active component of propolis, a honeybee hive product.1 Caffeic acid phenethyl ester is a specific inhibitor of the nuclear transcription factor, NF-κB.2 CAPE has been shown to significantly suppress the lipoxygenase pathway of arachidonic acid metabolism during inflammation.3,4 Caffeic acid phenethyl ester inhibits HIV-1 integrase,5,6 and also inhibits proliferation of transformed cells.7,8 It induces apoptosis in transformed fibroblasts,9 and interferes with EGF signal transduction affecting both protein kinase C and ornithine decarboxylase activity.7