Aloe-emodin

• Catalog No.: A7687
• CAS Number: 481-72-1
• M. F.: C15H10O5
• M. W.: 270.2369
• Purity: ≥95% (HPLC)

SYNONYMS

• IUPAC name: 1,8-dihydroxy-3-(hydroxymethyl)-9,10-dihydroanthracene-9,10-dione
• IUPAC Traditional name: aloe emodin
• Synonyms: 1,8-Dihydroxy-3-(hydroxymethyl)anthraquinone; 3-Hydroxymethylchrysazine

DATABASE IDS

• EC Number: 207-571-7
• PubChem SID: 24891267
• CAS Number: 481-72-1
• Beilstein Number: 2059062
• MDL Number: MFCD00017373

PROPERTIES

• Purity: ≥95% (HPLC)
• GHS Signal Word: Warning
• GHS Hazard statements: H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P261-P305 + P351 + P338
• Risk Statements: 36/37/38
• RTECS: CB6712200
• Safety Statements: 26-36
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Laxative/cathartic compound; increases the contraction of intestinal smooth muscle by releasing endogenous acetylcholine. Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, thus inducing a permeability transition that sets in motion a series of events culminating in cellular apoptosis. Genotoxicity and mutagenicity appear to be due to the inhibition of topoisomerase II activity by aloe emodin.