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2-Chloro-N6-cyclopentyladenosine_Molecular_structure_CAS_37739-05-2)
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2-Chloro-N6-cyclopentyladenosine

Catalog No. C7938 Name Sigma Aldrich
CAS Number 37739-05-2 Website http://www.sigmaaldrich.com
M. F. C15H20ClN5O4 Telephone 1-800-521-8956
M. W. 369.8034 Fax
Purity Email
Storage Chembase ID: 105640

SYNONYMS

IUPAC name
(2R,3R,4S,5R)-2-[2-chloro-6-(cyclopentylamino)-9H-purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
IUPAC Traditional name
ccpa (biochemistry)
Synonyms
CCPA

DATABASE IDS

CAS Number 37739-05-2
PubChem SID 24892583
MDL Number MFCD00078574

PROPERTIES

Gene Information human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140)rat ... Adora1(29290), Adora2a(25369), Adora3(25370)
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
RTECS AU7357555
Storage Temperature 2-8°C
German water hazard class 3

DETAILS

Description (English)
Biochem/physiol Actions
A1 adenosine receptor agonist with high selectivity: reportedly 10,000-fold for A1 over A2 receptors.
Application
2-Chloro-N6-cyclopentyladenosine (CCPA) may be used as an A1 adenosine receptor agonist with high selectivity. CCPA is often used with other adenosine receptor agonists and antagonist to resolve A(1), A(2A) and A(3) receptor functions. These include DPCPX (A(1) receptor antagonist), 4-(2-[7-amino-2-(2-furyl)[1,2,4]triazolo[2,3-α][1,3,5]triazin-5-ylamino]ethyl)phenol (A(2A) receptor antagonist), and 4-[2-[[6-amino-9-(N-ethyl-β-D-ribofuranuronamidosyl)-9H-purin-2-yl]amino]ethyl]benzenepropanoic acid hydrochloride (A(2A) receptor agonist), and Cl-IB-MECA, (A(3)) receptor agonist).

REFERENCES