Praziquantel

• Catalog No.: P4668
• CAS Number: 55268-74-1
• M. F.: C19H24N2O2
• M. W.: 312.40606

SYNONYMS

• Title: 吡喹酮
• IUPAC name: 2-cyclohexanecarbonyl-1H,2H,3H,4H,6H,7H,11bH-piperazino[2,1-a]isoquinolin-4-one
• IUPAC Traditional name: praziquantel
• Synonyms: 2-(环己基羰基)-1,2,3,6,7-11b-六氢-4H-吡嗪并(2,1a)异喹啉-4-酮

DATABASE IDS

• PubChem SID: 24278635
• CAS Number: 55268-74-1
• MDL Number: MFCD00058531
• EC Number: 259-559-6
• Beilstein Number: 761557

PROPERTIES

• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• RTECS: UQ4150000
• Storage Temperature: -20°C
• German water hazard class: 1

DETAILS

Description (English)

Application
Praziquantel is a potent anthelmintic used in against schistosome and many cestode infestations. It is used to study voltage-gated Ca2+ channels and is a potential small molecule neurogenic1.
Biochem/physiol Actions
Praziquantel increases the permeability of the tegmentum to Ca2+ which results in the contraction of schistosomes and death. Praziquantel causes vacuolization and disintegration of the schistosome tegument. It is more effective on adult worms than young worms. It inhibits glucose uptake, which lowers glycogen levels and stimulates lactate release