Tamoxifen

• Catalog No.: T5648
• CAS Number: 10540-29-1
• M. F.: C26H29NO
• M. W.: 371.51456
• Purity: ≥99%

SYNONYMS

• Title: 他莫昔芬
• IUPAC name: (2-{4-[(1Z)-1,2-diphenylbut-1-en-1-yl]phenoxy}ethyl)dimethylamine
• IUPAC Traditional name: tamoxifen
• Synonyms: (Z)-2-[4-(1,2-二苯基-1-丁烯)苯氧基]-N,N-二甲基乙胺; (Z)-1-(对二甲基氨基乙氧基苯基)-1,2-二苯基-1-丁烯

DATABASE IDS

• PubChem SID: 24900307
• MDL Number: MFCD00010454
• EC Number: 234-118-0
• CAS Number: 10540-29-1

PROPERTIES

• Purity: ≥99%
• Gene Information: human ... CYP1A2(1544), EBP(10682), ESR1(2099), ESR2(2100), ESRRA(2101)rat ... Ar(24208), Esr1(24890)
• Melting Point: 97-98 °C(lit.)
• GHS Signal Word: Danger
• GHS Hazard statements: H350-H360-H362
• European Hazard Symbols: Toxic (T)
• Personal Protective Equipment: Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS Precautionary statements: P201-P263-P308 + P313
• Risk Statements: 45-60-61-64
• RTECS: KR5919600
• Safety Statements: 53-45
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (简体中文)

Frequently Asked Questions
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General description
Tamoxifen is a selective estrogen response modifier (SERM), protein kinase C inhibitor and anti-angiogenetic factor. Tamoxifen is a prodrug that is metabolized to active metabolites 4-hydroxytamoxifen (4-OHT) and endoxifen by cytochrome P450 isoforms CYP2D6 and CYP3A4. In breast cancer, the gene repressor activity of tamoxifen against ERBB2 is dependent upon PAX2. Blocks estradiol-stimulated VEGF production in breast tumor cells.
Biochem/physiol Actions
蛋白激酶 C 抑制剂。诱发人类恶性神经胶质瘤细胞系的细胞凋亡。他莫昔芬及其代谢产物 4-羟基他莫昔芬是选择性雌激素反应调节剂 (SERM)，在乳腺中用作雌激素拮抗剂。阻止乳腺肿瘤细胞中雌二醇刺激的 VEGF 的产生。