Sulfachloropyridazine

• Catalog No.: S9882
• CAS Number: 80-32-0
• M. F.: C10H9ClN4O2S
• M. W.: 284.72206

SYNONYMS

• Title: 磺胺氯哒嗪
• IUPAC name: 4-amino-N-(6-chloropyridazin-3-yl)benzene-1-sulfonamide
• IUPAC Traditional name: sulfachloropyridazine
• Synonyms: 4-氨基-N-(6-氯-3-哒嗪基)苯磺酰胺

DATABASE IDS

• PubChem SID: 24899860
• Beilstein Number: 261558
• EC Number: 201-269-9
• MDL Number: MFCD00057371
• CAS Number: 80-32-0

PROPERTIES

• Suitability: suitable for 1694 per US EPA
• GHS Signal Word: Warning
• GHS Hazard statements: H317
• European Hazard Symbols: Irritant (Xi)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• GHS Precautionary statements: P280
• Risk Statements: 43
• Safety Statements: 36/37
• German water hazard class: 3

DETAILS

Description (English)

Application
Sulfachloropyridazine is a sulfonamide antibiotic that is used to study kinetics, reaction pathways and toxicity evolution1. Sulfachloropyridazine has been used to treat acute urinary tract infections in pediatric patients2.
Biochem/physiol Actions
Sulfachloropyridazine is a sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfachloropyridazine is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid3. It is active against Gram positive bacteria, Gram negative bacteria and Chlamydia. Mode of resistance is via the alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis. Sulfachloropyridazine is rapidly absorbed and rapidly excreted in the urine4.