Furazolidone

• Catalog No.: F9505
• CAS Number: 67-45-8
• M. F.: C8H7N3O5
• M. W.: 225.15828

SYNONYMS

• Title: 呋喃唑酮
• IUPAC name: 3-[(E)-[(5-nitrofuran-2-yl)methylidene]amino]-1,3-oxazolidin-2-one
• IUPAC Traditional name: furazolum
• Synonyms: 3-(5-硝基呋喃甲叉氨基)-2-噁唑烷酮

DATABASE IDS

• MDL Number: MFCD00010550
• EC Number: 200-653-3
• PubChem SID: 24894997
• CAS Number: 67-45-8
• Beilstein Number: 8317414

PROPERTIES

• GHS Signal Word: Warning
• GHS Hazard statements: H361
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS Precautionary statements: P281
• Risk Statements: 62
• RTECS: RQ3675000
• Safety Statements: 36
• German water hazard class: 3

DETAILS

Description (English)

Application
Furazolidone is a nitrofuran derivative with antiprotozoal and antibacterial activity. Furazolidone binds bacterial DNA, which leads to the gradual inhibition of monoamine oxidase. It is used to treat anorexia and antagonism of thiamin utilization in poultry1. Furazolidone increases thapsigargin-sensitive Ca2+-ATPase in chick cardiac myocytes2.
Biochem/physiol Actions
Furazolidone and its generated free radicals, may bind to DNA and induce cross-links. Bacterial DNA is particularly susceptible to this drug, which results in high levels of mutations (transitions and transversions) in the bacterial chromosome. Its mechanism of action minimizes the development of resistant organisms. Furazolidone is a monoamine oxidase (MAO) inhibitor. It increases thapsigargin-sensitive Ca2+-ATPase in chick cardiac myocytes2.
Furazolidone is a monoamine oxidase (MAO) inhibitor and is used as a DNA interstrand cross-linking agent.