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Furazolidone

Catalog No. F9505 Name Sigma Aldrich
CAS Number 67-45-8 Website http://www.sigmaaldrich.com
M. F. C8H7N3O5 Telephone 1-800-521-8956
M. W. 225.15828 Fax
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Storage Chembase ID: 496

SYNONYMS

Title
呋喃唑酮
IUPAC name
3-[(E)-[(5-nitrofuran-2-yl)methylidene]amino]-1,3-oxazolidin-2-one
IUPAC Traditional name
furazolum
Synonyms
3-(5-硝基呋喃甲叉氨基)-2-噁唑烷酮

DATABASE IDS

MDL Number MFCD00010550
EC Number 200-653-3
PubChem SID 24894997
CAS Number 67-45-8
Beilstein Number 8317414

PROPERTIES

GHS Signal Word Warning
GHS Hazard statements H361
European Hazard Symbols Harmful Harmful (Xn)
Personal Protective Equipment Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
GHS Precautionary statements P281
Risk Statements 62
RTECS RQ3675000
Safety Statements 36
German water hazard class 3
GHS Pictograms GHS08

DETAILS

Description (English)
Application
Furazolidone is a nitrofuran derivative with antiprotozoal and antibacterial activity. Furazolidone binds bacterial DNA, which leads to the gradual inhibition of monoamine oxidase. It is used to treat anorexia and antagonism of thiamin utilization in poultry1. Furazolidone increases thapsigargin-sensitive Ca2+-ATPase in chick cardiac myocytes2.
Biochem/physiol Actions
Furazolidone and its generated free radicals, may bind to DNA and induce cross-links. Bacterial DNA is particularly susceptible to this drug, which results in high levels of mutations (transitions and transversions) in the bacterial chromosome. Its mechanism of action minimizes the development of resistant organisms. Furazolidone is a monoamine oxidase (MAO) inhibitor. It increases thapsigargin-sensitive Ca2+-ATPase in chick cardiac myocytes2.
Furazolidone is a monoamine oxidase (MAO) inhibitor and is used as a DNA interstrand cross-linking agent.

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