Sulfathiazole sodium salt

• Catalog No.: S0127
• CAS Number: 144-74-1
• M. F.: C9H8N3NaO2S2
• M. W.: 277.29849
• Purity: ≥99%

SYNONYMS

• Title: 磺胺噻唑 钠盐
• IUPAC name: 4-amino-N-sodio-N-(1,3-thiazol-2-yl)benzene-1-sulfonamide
• IUPAC Traditional name: 4-amino-N-sodio-N-(1,3-thiazol-2-yl)benzenesulfonamide
• Synonyms: 4-Amino-N-(2-thiazolyl)benzenesulfonamide sodium salt

DATABASE IDS

• CAS Number: 144-74-1
• MDL Number: MFCD00072133
• EC Number: 205-638-5
• PubChem SID: 24899426
• Beilstein Number: 3802297

PROPERTIES

• Purity: ≥99%
• GHS Signal Word: Warning
• GHS Hazard statements: H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P261-P305 + P351 + P338
• Risk Statements: 36/37/38
• RTECS: WP2450000
• Safety Statements: 26-36
• German water hazard class: 2

DETAILS

Description (English)

Application
Sulfathiazole is a short-acting sulfa drug. It was a common oral and topical antibiotic until less toxic alternatives were discovered. It is no longer used in humans1. Sulfathiazole is added to the diet of laboratory animals to inhibit folate formation by gut bacteria. This ensures that the animal’s only source of available folate is from their diet2.
Biochem/physiol Actions
Sulfathiazole is a sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfathiazole is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid1. It is active against Gram positive bacteria, Gram negative bacteria and Chlamydia. Mode of resistance is via the alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis.