Wortmannin

• Catalog No.: W1628
• CAS Number: 19545-26-7
• M. F.: C23H24O8
• M. W.: 428.43186
• Purity: ≥98% (HPLC and TLC)

SYNONYMS

• IUPAC name: (1R,3R,5S,9R,18S)-18-(methoxymethyl)-1,5-dimethyl-6,11,16-trioxo-13,17-dioxapentacyclo[10.6.1.0^2,^1^0.0^5,^9.0^1^5,^1^9]nonadeca-2(10),12(19),14-trien-3-yl acetate
• IUPAC Traditional name: wortmannin
• Synonyms: KY 12420

DATABASE IDS

• CAS Number: 19545-26-7
• PubChem SID: 24278777
• MDL Number: MFCD00133927
• Beilstein Number: 67676

PROPERTIES

• Biological Source: from Penicillium funiculosum
• Purity: ≥98% (HPLC and TLC)
• Quality Level: PREMIUM
• Gene Information: human ... PIK3CD(5293), PIK3CG(5294), PIK3R1(5295)
• Apperance: off-white powder
• Solubility: DMSO: soluble
• Solubility: H2O: unstable
• GHS Signal Word: Danger
• GHS Hazard statements: H300-H310-H330
• European Hazard Symbols: Highly toxic (T+)
• Personal Protective Equipment: Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS Precautionary statements: P260-P264-P280-P284-P302 + P350-P310
• RID/ADR: UN 3462 6.1/PG 1
• Risk Statements: 26/27/28
• RTECS: CB9641000
• Safety Statements: 28-36/37-45
• Storage Temperature: 2-8°C
• Hazard Class: 6.1
• UN Number: 3462
• Packing Group: 1
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Wortmannin is a potent and specific phosphatidylinositol 3-kinase (PI3-K) inhibitor with an IC50 of 2-4 nM. Inhibition of PI3-K/Akt signal transduction cascade enhances the apoptotic effects of radiation or serum withdrawal and blocks the antiapoptotic effect of cytokines. Inhibition of PI3-K by wortmannin also blocks many of the short-term metabolic effects induced by insulin receptor activation.