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Catalog No. W1628 Name Sigma Aldrich
CAS Number 19545-26-7 Website http://www.sigmaaldrich.com
M. F. C23H24O8 Telephone 1-800-521-8956
M. W. 428.43186 Fax
Purity ≥98% (HPLC and TLC) Email
Storage Chembase ID: 5687


IUPAC name
(1R,3R,5S,9R,18S)-18-(methoxymethyl)-1,5-dimethyl-6,11,16-trioxo-13,17-dioxapentacyclo[,10.05,9.015,19]nonadeca-2(10),12(19),14-trien-3-yl acetate
IUPAC Traditional name
KY 12420


CAS Number 19545-26-7
PubChem SID 24278777
MDL Number MFCD00133927
Beilstein Number 67676


Biological Source from Penicillium funiculosum
Purity ≥98% (HPLC and TLC)
Quality Level PREMIUM
Gene Information human ... PIK3CD(5293), PIK3CG(5294), PIK3R1(5295)
Apperance off-white powder
Solubility DMSO: soluble
Solubility H2O: unstable
GHS Pictograms GHS06
GHS Signal Word Danger
GHS Hazard statements H300-H310-H330
European Hazard Symbols Highly toxic Highly toxic (T+)
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
GHS Precautionary statements P260-P264-P280-P284-P302 + P350-P310
RID/ADR UN 3462 6.1/PG 1
Risk Statements 26/27/28
RTECS CB9641000
Safety Statements 28-36/37-45
Storage Temperature 2-8°C
Hazard Class 6.1
UN Number 3462
Packing Group 1
German water hazard class 3


Description (English)
Biochem/physiol Actions
Wortmannin is a potent and specific phosphatidylinositol 3-kinase (PI3-K) inhibitor with an IC50 of 2-4 nM. Inhibition of PI3-K/Akt signal transduction cascade enhances the apoptotic effects of radiation or serum withdrawal and blocks the antiapoptotic effect of cytokines. Inhibition of PI3-K by wortmannin also blocks many of the short-term metabolic effects induced by insulin receptor activation.