15(S)-Hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoic acid

• Catalog No.: H1142
• CAS Number: 54845-95-3
• M. F.: C20H32O3
• M. W.: 320.46628
• Purity: ≥97.0% (HPLC)

SYNONYMS

• IUPAC name: (5Z,8Z,11Z,13E,15S)-15-hydroxyicosa-5,8,11,13-tetraenoic acid
• IUPAC Traditional name: 15 hete
• Synonyms: (15S,5Z,8Z,11Z,13E)-15-Hydroxyeicosatetraenoic acid; (S)-15-HETE; 15(S)-HETE

DATABASE IDS

• PubChem SID: 24895431
• MDL Number: MFCD00063590
• Beilstein Number: 2470466
• CAS Number: 54845-95-3

PROPERTIES

• Concentration: ~150 μg/mL in ethanol
• Purity: ≥97.0% (HPLC)
• Shipped in: dry ice
• Flash Point: 14 °C
• Flash Point: 57.2 °F
• GHS Signal Word: Danger
• GHS Hazard statements: H225-H315-H319-H335
• European Hazard Symbols: Flammable (F)
• European Hazard Symbols: Irritant (Xi)
• Personal Protective Equipment: Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
• GHS Precautionary statements: P210-P261-P305 + P351 + P338
• RID/ADR: UN 1170 3/PG 2
• Risk Statements: 11-36/37/38
• Safety Statements: 7-16-26-36
• Storage Temperature: -20°C
• Hazard Class: 3
• UN Number: 1170
• Packing Group: 2
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Metabolite of arachidonic acid via the 15-lipoxygenase pathway that may be involved in pulmonary anti-inflammatory responses through the inhibition of 5-lipoxygenase. 15(S)-HETE suppresses the incorporation of thymidine and biosynthesis of prostaglandin E2 in tumor cell cultures. Treatment of colon cancer cells with 15(S)-HETE inhibited cell proliferation and induced apoptosis, which was preceded by an increase in TGF-beta-inducible early gene (TIEG) and a decrease in Bcl-2.