Calcium Ionophore A23187 hemimagnesium salt

• Catalog No.: C9400
• CAS Number: 72124-77-7
• M. F.: C58H72MgN6O12
• M. W.: 1069.53028

SYNONYMS

• Title: Calcium Ionophore A23187
• IUPAC name: [5-(methylamino)-2-{[(2R,3R,6S,8S,9R,11R)-3,9,11-trimethyl-8-[(2S)-1-oxo-1-(1H-pyrrol-2-yl)propan-2-yl]-1,7-dioxaspiro[5.5]undecan-2-yl]methyl}-1,3-benzoxazole-4-carbonyloxy]magnesio 5-(methylamino)-2-{[(2R,3R,6S,8S,9R,11R)-3,9,11-trimethyl-8-[(2S)-1-oxo-1-(1H-pyrrol-2-yl)propan-2-yl]-1,7-dioxaspiro[5.5]undecan-2-yl]methyl}-1,3-benzoxazole-4-carboxylate
• IUPAC Traditional name: [5-(methylamino)-2-{[(2R,3R,6S,8S,9R,11R)-3,9,11-trimethyl-8-[(2S)-1-oxo-1-(1H-pyrrol-2-yl)propan-2-yl]-1,7-dioxaspiro[5.5]undecan-2-yl]methyl}-1,3-benzoxazole-4-carbonyloxy]magnesio 5-(methylamino)-2-{[(2R,3R,6S,8S,9R,11R)-3,9,11-trimethyl-8-[(2S)-1-oxo-1-(1H-pyrrol-2-yl)propan-2-yl]-1,7-dioxaspiro[5.5]undecan-2-yl]methyl}-1,3-benzoxazole-4-carboxylate
• Synonyms: Calcimycin hemimagnesium salt; A23187; Calimycin 半镁盐; Antibiotic A 23187

DATABASE IDS

• MDL Number: MFCD00151203
• Beilstein Number: 6765085
• CAS Number: 72124-77-7
• PubChem SID: 24893158

PROPERTIES

• GHS Signal Word: Warning
• GHS Hazard statements: H302-H312-H315-H319-H332-H335
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P261-P280-P305 + P351 + P338
• Risk Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Application
Ionophore highly selective for Ca2+. Potentiates responses to NMDA but not quisqualate. In cell culture, stimulates nitric oxide production by calmodulin-dependent constitutive nitric oxide synthase. Used to study effects of elevated intracellular calcium on mitochondrial function and intrinsic apoptosis.