4-(N-Maleimidomethyl)cyclohexanecarboxylic acid N-hydroxysuccinimide ester

• Catalog No.: M5525
• CAS Number: 64987-85-5
• M. F.: C16H18N2O6
• M. W.: 334.32392
• Purity: ≥98%

SYNONYMS

• Title: 4-(N-马来酰亚胺基甲基)环己烷-1-羧酸琥珀酰亚胺酯
• IUPAC name: 2,5-dioxopyrrolidin-1-yl 4-[(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl]cyclohexane-1-carboxylate
• IUPAC Traditional name: SMCC
• Synonyms: SMCC; N-琥珀酰亚胺基4-(马来酰亚胺基甲基)环己烷羧酸酯

DATABASE IDS

• CAS Number: 64987-85-5
• PubChem SID: 24897020
• Beilstein Number: 1555271
• MDL Number: MFCD00009634

PROPERTIES

• Purity: ≥98%
• Shipped in: wet ice
• Apperance: powder
• Melting Point: 180-182 °C(lit.)
• Solubility: chloroform: soluble50 mg/mL
• Solubility: DMF: soluble
• GHS Signal Word: Warning
• GHS Hazard statements: H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P261-P305 + P351 + P338
• Risk Statements: 36/37/38
• Safety Statements: 26-36
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (English)

Application
A heterobifunctional cross-linking reagent incorporating an extended spacer with amine and sulfhydryl reactivity. Typically coupled initially to molecules containing primary amine by amide bond buffered at pH 7.5 (6.5-8.5). The second coupling is specific for molecules containing free sulfhydryl by thioether linkage buffered at pH 6.8 (6.5-7.0). Useful for preparation of enzyme immunoconjugates and hapten carrier molecule conjugates. Contains 9 atom linker. An extended aliphatic spacer stabilizes the maleimide prior to coupling compared to aromatic spacers.