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Catalog No. T4014 Name Sigma Aldrich
CAS Number 32986-56-4 Website http://www.sigmaaldrich.com
M. F. C18H37N5O9 Telephone 1-800-521-8956
M. W. 467.51448 Fax
Purity Email
Storage Chembase ID: 133769


IUPAC name
IUPAC Traditional name


MDL Number MFCD00077885
Beilstein Number 1357507
PubChem SID 24900188
CAS Number 32986-56-4
EC Number 251-322-5


RTECS WK2100000
Storage Temperature 2-8°C
German water hazard class 2


Description (English)
Biochem/physiol Actions
Tobramycin is an aminoglycoside. Mode of Action: Binds to 70S ribosomal subunit; inhibits translocation; elicits miscoding. Spectrum of Activity: Gram negative bacteria. Not effective against Enterococci.
Tobramycin binds irreversibly to one of two aminoglycoside binding sites on the 30 S ribosomal subunit, inhibiting bacterial protein synthesis. Tobramycin may also destabilize bacterial membranes by binding to 16 S r-RNA. It inhibits translocation and elicits miscoding.
Tobramycin is an aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteria, especially the pseudomonas species. It is not effective against Enterococci. It is used to inhibit bacterial protein synthesis. It is used to treat pseudomonas aeruginosa lung infections and is used in combination with other antibiotics to treat urinary tract infections, gynecologic infections, peritonitis, endocarditis, pneumonia, sepsis, respiratory infections, osteomyelitis, and other soft-tissue infections. It is a potential therapy for sinus infections1.