α-Endorphin human

• Catalog No.: E6136
• CAS Number: 59004-96-5
• M. F.: C77H120N18O26S
• M. W.: 1745.9467
• Purity: ≥97% (HPLC)

SYNONYMS

• IUPAC name: (4S)-4-{[(1S)-5-amino-1-{[(1S)-1-{[(1S)-3-carbamoyl-1-{[(2S,3R)-1-[(2S)-2-{[(1S)-1-{[(1S)-1-{[(1S,2R)-1-carboxy-2-hydroxypropyl]carbamoyl}-2-methylpropyl]carbamoyl}-3-methylbutyl]carbamoyl}pyrrolidin-1-yl]-3-hydroxy-1-oxobutan-2-yl]carbamoyl}propyl]carbamoyl}-2-hydroxyethyl]carbamoyl}pentyl]carbamoyl}-4-[(2S)-2-[(2S,3R)-2-[(2S)-2-[(2S)-2-(2-{2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamido]acetamido}acetamido)-3-phenylpropanamido]-4-(methylsulfanyl)butanamido]-3-hydroxybutanamido]-3-hydroxypropanamido]butanoic acid
• IUPAC Traditional name: α-endorphin
• Synonyms: β-Lipotropin (61-76), human, synthetic; LPH (61-76); Tyr-Gly-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr; β-Lipotropin 61-76

DATABASE IDS

• CAS Number: 59004-96-5
• PubChem SID: 24894621
• MDL Number: MFCD00076381

PROPERTIES

• Purity: ≥97% (HPLC)
• Gene Information: human ... POMC(5443)
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (English)

Amino Acid Sequence
Tyr-Gly-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr
Biochem/physiol Actions
α-endorphin is the 1-16 fragment of β-endorphin. It is a substrate for transglutaminase and both α-endorphin and its acetylated form are found in intermediate and anterior lobes of the pituitary. It appears to bind to neuronal opiate receptors, but does not bind to β-endorphin receptors in lymphocytes, vasculature, or vas deferens. Stimulatory effects on immune system function have been reported.