Colistin sodium methanesulfonate

• Catalog No.: C1511
• CAS Number: 8068-28-8
• M. F.: C58H115N16Na5O28S5
• M. W.: 1759.89795

SYNONYMS

• IUPAC name: pentasodium N-[(1S)-3-amino-1-{[(1S,2R)-1-{[(1S)-3-amino-1-{[(3S,6S,9R,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-3-[(1R)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl]carbamoyl}propyl]carbamoyl}-2-hydroxypropyl]carbamoyl}propyl]-6-methyloctanamide pentamethanesulfonate
• IUPAC Traditional name: pentasodium N-[(1S)-3-amino-1-{[(1S,2R)-1-{[(1S)-3-amino-1-{[(3S,6S,9R,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-3-[(1R)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl]carbamoyl}propyl]carbamoyl}-2-hydroxypropyl]carbamoyl}propyl]-6-methyloctanamide pentamesylate
• Synonyms: Polymyxin E sodium methanesulfonate; Colimycin sodium methanesulfonate; Methanesulfonic acid derivative of Polymyxin E

DATABASE IDS

• PubChem SID: 24892418
• MDL Number: MFCD00130824
• CAS Number: 8068-28-8
• EC Number: 232-516-9

PROPERTIES

• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• RTECS: GH1650000
• Storage Temperature: 2-8°C
• German water hazard class: 2

DETAILS

Description (English)

Biochem/physiol Actions
Mode of Action: Binds to lipids on the cell cytoplasmic membrane of Gram-negative bacteria and disrupts the cell wall integrity.Antimicrobial spectrum: Gram-negative bacteria.
Cyclopolypeptide antibiotic. Endotoxin-binding capacity3 Colistin′s activity stems from the hydrophobic and hydrophillic regions. They solubilze the cytoplasmic membrane which contributes to the bactericidal effect 4.
Application
Colistin sodium methanesulfate is used to permeabilize bacterial cell membranes and to study mannose-resistant haemagglutination. It is used to study effective treatments of P. aeruginosa infections in cystic fibrosis patients 1 and to study the pharmacokinetics and BAL concentration of colistin in critically ill patients 2.
Protocols & Applications
Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information