(S)-(-)-Propranolol hydrochloride

• Catalog No.: P8688
• CAS Number: 4199-10-4
• M. F.: C16H22ClNO2
• M. W.: 295.80438
• Purity: ≥98% (TLC)

SYNONYMS

• Title: (S)-(-)-普奈洛尔 盐酸盐
• IUPAC name: [(2S)-2-hydroxy-3-(naphthalen-1-yloxy)propyl](propan-2-yl)amine hydrochloride
• IUPAC Traditional name: [(2S)-2-hydroxy-3-(naphthalen-1-yloxy)propyl](isopropyl)amine hydrochloride
• Synonyms: (S)-1-异丙基氨基-3-(1-萘氧基)-2-丙醇 盐酸盐

DATABASE IDS

• MDL Number: MFCD00064547
• CAS Number: 4199-10-4
• PubChem SID: 24278657
• EC Number: 224-096-0
• Beilstein Number: 3574966

PROPERTIES

• Purity: ≥98% (TLC)
• Gene Information: human ... ADRB1(153), ADRB2(154), ADRB3(155), HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355)
• Apperance: powder
• Melting Point: 193-195 °C(lit.)
• Optical Rotation: [α]25/D -25.5°, c = 1.0 in ethanol(lit.)
• Solubility: ethanol: soluble10 mg/mL
• Solubility: DMSO: <14.5 mg/mL
• Solubility: H2O: soluble50 mg/mL (With heat. Aqueous solutions are most stable at pH 3.0 and decompose rapidly at basic pH. Decomposition is accompanied by discoloration of the solution.)
• Solubility: 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: soluble8.0 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H302-H312-H332
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P280
• Risk Statements: 20/21/22
• Safety Statements: 36
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (简体中文)

包装
100, 500 mg in glass bottle
Biochem/physiol Actions
Active β-adrenoceptor blocking enantiomer, as measured by inhibition of isoprenaline-induced tachycardia; Propranolol is also non-specific 5-HT1A, 5-HT1B and 5-HT1C serotonin receptor antagonist. The stereoselective association of mianserin and propranolol with the 5HT1A, 5HT1B and 5HT1C sites may prove useful in the characterization of these sites