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Prostaglandin I2 sodium salt_Molecular_structure_CAS_61849-14-7)
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Prostaglandin I2 sodium salt

Catalog No. P6188 Name Sigma Aldrich
CAS Number 61849-14-7 Website http://www.sigmaaldrich.com
M. F. C20H31NaO5 Telephone 1-800-521-8956
M. W. 374.44691 Fax
Purity ≥96% (HPLC) Email
Storage Chembase ID: 133752

SYNONYMS

IUPAC name
sodium 5-[(3E,3aS,4R,5R,6aS)-5-hydroxy-4-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-hexahydro-2H-cyclopenta[b]furan-3-ylidene]pentanoate
IUPAC Traditional name
sodium 5-[(3E,3aS,4R,5R,6aS)-5-hydroxy-4-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-hexahydrocyclopenta[b]furan-3-ylidene]pentanoate
Synonyms
PGI2-Na
Epoprostenol 钠
(5Z,9α,11α,13E,15S)-6,9-Epoxy-11,15-dihydroxyprosta-5,13-dien-1-oic acid sodium salt
Prostacyclin sodium salt

DATABASE IDS

PubChem SID 24898653
MDL Number MFCD00135629
EC Number 263-273-7
CAS Number 61849-14-7
Beilstein Number 6472195

PROPERTIES

Biological Source synthetic
Purity ≥96% (HPLC)
Apperance white to off-white powder
Solubility H2O: soluble1 mg/mL (Hydrolyzes to 6-ketoprostaglandin F1α in aqueous solution.)
Solubility ethanol: soluble50 mg/mL
GHS Pictograms GHS07
GHS Signal Word Warning
GHS Hazard statements H302-H312-H332
European Hazard Symbols Harmful Harmful (Xn)
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
GHS Precautionary statements P280
Risk Statements 20/21/22
Safety Statements 22-26-36
Storage Temperature -20°C
German water hazard class 3

DETAILS

Description (English)
Biochem/physiol Actions
Prostacyclin is a short-lived product of the cyclooxygenase pathway in vascular endothelial cells. It is a potent inhibitor of platelet aggregation by antagonizing thromboxane A2 and stimulating platelet adenylyl cyclase.1 Nitric oxide is also produced in vascular endothelium where it inhibits platelet aggregation, regulates inducible cyclooxygenase production, and may work synergistically with prostacyclin to attenuate the thrombotic process. Prostacyclin is vasoprotective, protecting arterial walls from injury-induced lesions and cytoprotective in the liver and gastrointestinal tract.
Prostacyclin therapy improves hemodynamics in pulmonary arterial hypertension.

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