Prostaglandin I2 sodium salt

• Catalog No.: P6188
• CAS Number: 61849-14-7
• M. F.: C20H31NaO5
• M. W.: 374.44691
• Purity: ≥96% (HPLC)

SYNONYMS

• IUPAC name: sodium 5-[(3E,3aS,4R,5R,6aS)-5-hydroxy-4-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-hexahydro-2H-cyclopenta[b]furan-3-ylidene]pentanoate
• IUPAC Traditional name: sodium 5-[(3E,3aS,4R,5R,6aS)-5-hydroxy-4-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-hexahydrocyclopenta[b]furan-3-ylidene]pentanoate
• Synonyms: PGI2-Na; Epoprostenol 钠; (5Z,9α,11α,13E,15S)-6,9-Epoxy-11,15-dihydroxyprosta-5,13-dien-1-oic acid sodium salt; Prostacyclin sodium salt

DATABASE IDS

• PubChem SID: 24898653
• MDL Number: MFCD00135629
• EC Number: 263-273-7
• CAS Number: 61849-14-7
• Beilstein Number: 6472195

PROPERTIES

• Biological Source: synthetic
• Purity: ≥96% (HPLC)
• Apperance: white to off-white powder
• Solubility: H2O: soluble1 mg/mL (Hydrolyzes to 6-ketoprostaglandin F1α in aqueous solution.)
• Solubility: ethanol: soluble50 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H302-H312-H332
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P280
• Risk Statements: 20/21/22
• Safety Statements: 22-26-36
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Prostacyclin is a short-lived product of the cyclooxygenase pathway in vascular endothelial cells. It is a potent inhibitor of platelet aggregation by antagonizing thromboxane A2 and stimulating platelet adenylyl cyclase.1 Nitric oxide is also produced in vascular endothelium where it inhibits platelet aggregation, regulates inducible cyclooxygenase production, and may work synergistically with prostacyclin to attenuate the thrombotic process. Prostacyclin is vasoprotective, protecting arterial walls from injury-induced lesions and cytoprotective in the liver and gastrointestinal tract.
Prostacyclin therapy improves hemodynamics in pulmonary arterial hypertension.