Azaserine

• Catalog No.: A4142
• CAS Number: 115-02-6
• M. F.: C5H7N3O4
• M. W.: 173.12678
• Purity: ≥98% (TLC)

SYNONYMS

• Title: 偶氮丝氨酸
• IUPAC name: (2S)-2-amino-3-[(2-diazoacetyl)oxy]propanoic acid
• IUPAC Traditional name: azaserine
• Synonyms: O-重氮乙酰基-L-丝氨酸

DATABASE IDS

• PubChem SID: 24890830
• EC Number: 204-061-6
• Beilstein Number: 1726602
• CAS Number: 115-02-6
• MDL Number: MFCD00036802

PROPERTIES

• Purity: ≥98% (TLC)
• GHS Signal Word: Danger
• GHS Hazard statements: H301-H351
• European Hazard Symbols: Toxic (T)
• Personal Protective Equipment: Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS Precautionary statements: P281-P301 + P310
• RID/ADR: UN 3462 6.1/PG 3
• Risk Statements: 25-40
• RTECS: VT9625000
• Safety Statements: 53-36/37/39-45
• Storage Temperature: -20°C
• Hazard Class: 6.1
• UN Number: 3462
• Packing Group: 3
• German water hazard class: 3

DETAILS

Description (English)

Application
Used in cell culture for the selection of HGPRT revertants.
Biochem/physiol Actions
Azaserine is an antibiotic and antifungal; it may also act as a tumor inducer. It is a structural analog of glutamine and competes with glutamine in binding to enzymes involved in purine biosynthesis. Azaserine inhibits purine biosynthesis by covalently reacting with cysteine residues in the enzyme active sites, such as in formylglycinamide ribonucleotide amidotransferase and PRPP amidotransferase.1 Azaserine can induce DNA damage via the formation of carboxymethylated bases and O6-methylguanine. Secretion of exo-1,3-β-glucanase and germ-tube formation of Candida albicans were inhibited by azaserine.2