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Naloxone hydrochloride dihydrate_Molecular_structure_CAS_51481-60-8)
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Naloxone hydrochloride dihydrate

Catalog No. N7758 Name Sigma Aldrich
CAS Number 51481-60-8 Website http://www.sigmaaldrich.com
M. F. C19H26ClNO6 Telephone 1-800-521-8956
M. W. 399.86584 Fax
Purity ≥98% (TLC and titration) Email
Storage Chembase ID: 133745


IUPAC name
(1S,5R,13R,17S)-10,17-dihydroxy-4-(prop-2-en-1-yl)-12-oxa-4-azapentacyclo[,13.05,17.07,18]octadeca-7(18),8,10-trien-14-one dihydrate hydrochloride
IUPAC Traditional name
naloxone dihydrate hydrochloride


CAS Number 51481-60-8
Beilstein Number 6260807
MDL Number MFCD00150901
PubChem SID 24278050


Purity ≥98% (TLC and titration)
Gene Information human ... OPRD1(4985), OPRK1(4986), OPRM1(4988), OPRS1(10280)
Apperance white to off-white powder
Optical Rotation [α]25/D -178.6°, c = 2.5 in H2O(lit.)
Solubility ethanol: soluble3.3 mg/mL (stable for several months refrigerated if protected from light.)
Solubility H2O: soluble50 mg/mL (stable for several months refrigerated if protected from light.)
GHS Pictograms GHS07
GHS Signal Word Warning
GHS Hazard statements H315-H319-H335
European Hazard Symbols Irritant Irritant (Xi)
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
GHS Precautionary statements P261-P305 + P351 + P338
Risk Statements 36/37/38
Safety Statements 22-26
Storage Temperature 2-8°C
German water hazard class 3


Description (English)
Biochem/physiol Actions
Competitive antagonist for μ, κ, δ, and σ opioid receptors; blocks the action of σ-agonists at opioid sites.
Light sensitive.