Naloxone hydrochloride dihydrate

• Catalog No.: N7758
• CAS Number: 51481-60-8
• M. F.: C19H26ClNO6
• M. W.: 399.86584
• Purity: ≥98% (TLC and titration)

SYNONYMS

• IUPAC name: (1S,5R,13R,17S)-10,17-dihydroxy-4-(prop-2-en-1-yl)-12-oxa-4-azapentacyclo[9.6.1.0^1,^1^3.0^5,^1^7.0^7,^1^8]octadeca-7(18),8,10-trien-14-one dihydrate hydrochloride
• IUPAC Traditional name: naloxone dihydrate hydrochloride

DATABASE IDS

• CAS Number: 51481-60-8
• Beilstein Number: 6260807
• MDL Number: MFCD00150901
• PubChem SID: 24278050

PROPERTIES

• Purity: ≥98% (TLC and titration)
• Gene Information: human ... OPRD1(4985), OPRK1(4986), OPRM1(4988), OPRS1(10280)
• Apperance: white to off-white powder
• Optical Rotation: [α]25/D -178.6°, c = 2.5 in H2O(lit.)
• Solubility: ethanol: soluble3.3 mg/mL (stable for several months refrigerated if protected from light.)
• Solubility: H2O: soluble50 mg/mL (stable for several months refrigerated if protected from light.)
• GHS Signal Word: Warning
• GHS Hazard statements: H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P261-P305 + P351 + P338
• Risk Statements: 36/37/38
• Safety Statements: 22-26
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Competitive antagonist for μ, κ, δ, and σ opioid receptors; blocks the action of σ-agonists at opioid sites.
Caution
Light sensitive.