cis-Diammineplatinum(II) dichloride

• Catalog No.: P4394
• CAS Number: 15663-27-1
• M. F.: Cl2H6N2Pt
• M. W.: 300.04504

SYNONYMS

• Title: 顺铂
• IUPAC name: dichloroplatinum diamine
• IUPAC Traditional name: platinum(II) chloride diamine
• Synonyms: 顺-二氯二氨基铂(II); 顺式-二胺二氯铂; 顺氯氨铂

DATABASE IDS

• CAS Number: 15663-27-1
• PubChem SID: 24278632
• MDL Number: MFCD00011623
• EC Number: 239-733-8

PROPERTIES

• Apperance: yellow crystalline
• Melting Point: 270 °C(lit.)
• GHS Signal Word: Danger
• GHS Hazard statements: H300-H318-H350
• European Hazard Symbols: Toxic (T)
• GHS Precautionary statements: P201-P264-P280-P301 + P310-P305 + P351 + P338-P308 + P313
• RID/ADR: UN 3288 6.1/PG 2
• Risk Statements: 45-25-41
• RTECS: TP2450000
• Safety Statements: 53-26-39-45
• Hazard Class: 6.1
• UN Number: 3288
• Packing Group: 2
• German water hazard class: 3

DETAILS

Description (简体中文)

Frequently Asked Questions
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Biochem/physiol Actions
强效的铂基抗肿瘤剂。与 DNA 二核苷酸 d(pGpG) 形成细胞毒性加合物，诱导链内交联。
Potent chemoimmunotherapeutic drug; stimulates the immune responses by activating macrophages and other cells of the immune system. Cisplatin-treated macrophages show increased antigen presentation function in vitro. Treatment increased cellular NF-κB content and translocation in macrophages. Cisplatin effects are regulated by kinases, phosphatases, and Ca2+/calmodulin. Forms cytotoxic adducts with the DNA dinucleotide d(pGpG), inducing intrastrand crosslinks.
包装
1 g in glass bottle
25, 100, 250 mg in glass bottle