Kaempferol

• Catalog No.: K0133
• CAS Number: 520-18-3
• M. F.: C15H10O6
• M. W.: 286.2363
• Purity: ≥90% (HPLC)
• Storage: protect from light

SYNONYMS

• IUPAC name: 3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
• IUPAC Traditional name: kaempferol
• Synonyms: Robigenin; 3,4′,5,7-Tetrahydroxyflavone; 3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one

DATABASE IDS

• CAS Number: 520-18-3
• MDL Number: MFCD00016938
• Beilstein Number: 304401
• PubChem SID: 24896195

PROPERTIES

• Purity: ≥90% (HPLC)
• Gene Information: human ... CDC2(983), CDK5(1020), CDK6(1021), CYP1A2(1544), CYP2C9(1559), GSK3A(2931)mouse ... Hexa(15211)
• Apperance: yellow powder
• Solubility: ethanol: soluble20 mg/mL
• Solubility: DMSO: soluble50 mg/mL
• GHS Signal Word: Danger
• GHS Hazard statements: H301-H341
• European Hazard Symbols: Toxic (T)
• Personal Protective Equipment: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
• GHS Precautionary statements: P281-P301 + P310
• Risk Statements: 25-68
• Safety Statements: 36/37-45
• Storage Condition: protect from light
• Storage Temperature: room temp
• German water hazard class: 3

DETAILS

Description (English)

Application
Chromogenic reagent for antimony in the low ppm range2 and for gallium and indium in the sub-ppm range.3
Biochem/physiol Actions
A flavonol shown to revert the transformed phenotype of phorbol ester-treated mouse fibroblasts or v-H-ras-transformed NIH 3T3 cells. Induces significant nuclear DNA degradation concurrent with lipid peroxidation.4 Inhibits topoisomerase I catalyzed DNA religation.5 Kaempferol may also inhibit the activity of fatty acid synthase.
Potent inhibitor of osteoclastic bone resorption. The effect is believed to be attributable to both the antioxidant and estrogenic activities of kaempferol.1