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Dexamethasone

Catalog No. D9184 Name Sigma Aldrich
CAS Number 50-02-2 Website http://www.sigmaaldrich.com
M. F. C22H29FO5 Telephone 1-800-521-8956
M. W. 392.4610632 Fax
Purity Email
Storage Chembase ID: 1103

SYNONYMS

Title
地塞米松
IUPAC name
(1R,2S,10S,11S,13R,14R,15S,17S)-1-fluoro-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,13,15-trimethyltetracyclo[8.7.0.02,7.011,15]heptadeca-3,6-dien-5-one
IUPAC Traditional name
dexamethasone
Synonyms
德沙美松
9α-氟-16α-甲基氢化泼尼松
9-氟-11,17,21-三羟基-16-甲基(11b,16a)-孕甾-1,4-二烯-3,20-二酮
21α-乙酰氧基-9α-氟-11β,17α-二羟基-16α-甲基孕甾-1,4-二烯-3,20-二酮

DATABASE IDS

CAS Number 50-02-2
Beilstein Number 2066651
EC Number 200-003-9
MDL Number MFCD00064136
PubChem SID 24894273

PROPERTIES

Suitability meets USP testing specifications
Gene Information human ... ABCB1(5243), CYP3A4(1576), IL4(3565), IL5(3567), NR3C1(2908)mouse ... Abcb1a(18671), Abcb1b(18669), Ifng(15978), Nos2(18126), Ptgs2(19225), Tnf(21926)rat ... Ar(24208), Nr3c1(24413), Tnf(24835)
Melting Point 262-264 °C(lit.)
GHS Pictograms GHS07
GHS Pictograms GHS08
GHS Signal Word Danger
GHS Hazard statements H315-H317-H319-H334-H335
European Hazard Symbols Harmful Harmful (Xn)
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
GHS Precautionary statements P261-P280-P305 + P351 + P338-P342 + P311
Risk Statements 36/37/38-42/43
RTECS TU3980000
Safety Statements 22-26-36/37-45
Storage Temperature 2-8°C
German water hazard class 2

DETAILS

Description (简体中文)
Application
一种抗炎糖皮质素,对细胞存活、细胞信号传导和基因表达具有一系列的影响。用于研究细胞凋亡、细胞信号传导通路和基因表达。
Biochem/physiol Actions
糖皮质素抗炎剂。调控 T 细胞的存活、生长和分化。抑制一氧化氮合酶的诱导作用。

REFERENCES