Dexamethasone

• Catalog No.: D4902
• CAS Number: 50-02-2
• M. F.: C22H29FO5
• M. W.: 392.4610632
• Purity: ≥97%

SYNONYMS

• Title: 地塞米松
• IUPAC name: (1R,2S,10S,11S,13R,14R,15S,17S)-1-fluoro-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,13,15-trimethyltetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadeca-3,6-dien-5-one
• IUPAC Traditional name: dexamethasone
• Synonyms: 德沙美松; 9α-氟-16α-甲基氢化泼尼松; 9-氟-11,17,21-三羟基-16-甲基(11b,16a)-孕甾-1,4-二烯-3,20-二酮; 21α-乙酰氧基-9α-氟-11β,17α-二羟基-16α-甲基孕甾-1,4-二烯-3,20-二酮

DATABASE IDS

• CAS Number: 50-02-2
• Beilstein Number: 2066651
• EC Number: 200-003-9
• MDL Number: MFCD00064136
• PubChem SID: 24893906

PROPERTIES

• Potency: 4-500 ng/mL
• Purity: ≥97%
• Suitability: suitable for cell culture
• Gene Information: human ... ABCB1(5243), CYP3A4(1576), IL4(3565), IL5(3567), NR3C1(2908)mouse ... Abcb1a(18671), Abcb1b(18669), Ifng(15978), Nos2(18126), Ptgs2(19225), Tnf(21926)rat ... Ar(24208), Nr3c1(24413), Tnf(24835)
• Apperance: powder
• Melting Point: 262-264 °C(lit.)
• GHS Signal Word: Danger
• GHS Hazard statements: H315-H317-H319-H334-H335
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• GHS Precautionary statements: P261-P280-P305 + P351 + P338-P342 + P311
• Risk Statements: 36/37/38-42/43
• RTECS: TU3980000
• Safety Statements: 22-26-36/37-45
• Storage Temperature: 2-8°C
• German water hazard class: 2

DETAILS

Description (简体中文)

Frequently Asked Questions
Live Chat and Frequently Asked Questions are available for this Product.
Application
An anti-inflammatory glucocorticoid with a range of effects on cell survival, cell signaling and gene expression. Use to study apoptosis, cell signaling pathways and gene expression.
Reconstitution
To prepare 20 μg/ml stock solution, add 1ml absolute ethanol per mg product; gently swirl to dissolve. Add 49 ml sterile medium per ml of ethanol added, while mixing, to acheive final concentration of 20 μg/ml.
Physical form
powder 2-8 °C; stock-frozen in working aliquots, avoid repeated freeze/thaw
Biochem/physiol Actions
糖皮质素抗炎剂。调控 T 细胞的存活、生长和分化。抑制一氧化氮合酶的诱导作用。