Ampicillin trihydrate

• Catalog No.: A6140
• CAS Number: 7177-48-2
• M. F.: C16H25N3O7S
• M. W.: 403.4506
• Purity: 96.0-100.5% anhydrous basis (HPLC)

SYNONYMS

• Title: 氨苄西林 三水合物
• IUPAC name: (2S,5R,6R)-6-[(2R)-2-amino-2-phenylacetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid trihydrate
• IUPAC Traditional name: ampicillin trihydrate
• Synonyms: 氨苄青霉素

DATABASE IDS

• CAS Number: 7177-48-2
• Beilstein Number: 5399534
• MDL Number: MFCD00072036
• EC Number: 200-709-7
• PubChem SID: 24891059

PROPERTIES

• Purity: 96.0-100.5% anhydrous basis (HPLC)
• Melting Point: 198-200 °C (dec.)(lit.)
• GHS Signal Word: Danger
• GHS Hazard statements: H315-H317-H319-H334-H335
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• GHS Precautionary statements: P261-P280-P305 + P351 + P338-P342 + P311
• Risk Statements: 36/37/38-42/43
• RTECS: XH8425000
• Safety Statements: 22-26-36/37
• Storage Temperature: 2-8°C
• German water hazard class: 2

DETAILS

Description (English)

Biochem/physiol Actions
A β-lactam antibiotic with an amino group side chain attached to the penicillin structure. Penicillin derivative that inhibits bacterial cell-wall synthesis (peptidoglycan cross-linking) by inactivating transpeptidases on the inner surface of the bacterial cell membrane. Bactericidal only to growing Escherichia coli . Mode of resistance: Cleavage of β-lactam ring of ampicillin by β-lactamase. Antimicrobial spectrum: Gram-negative and Gram-positive bacteria.
Application
Ampicillin Trihydrate is commonly used to select for ampicillin resistance in mutated and transformed cells.