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Adenosine 5′-(β,γ-imido)triphosphate lithium salt hydrate_Molecular_structure_CAS_25612-73-1(freeacid))
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Adenosine 5′-(β,γ-imido)triphosphate lithium salt hydrate

Catalog No. A2647 Name Sigma Aldrich
CAS Number 25612-73-1(freeacid) Website http://www.sigmaaldrich.com
M. F. C10H15Li4N6O13P3 Telephone 1-800-521-8956
M. W. 547.943783 Fax
Purity ≥93% (HPLC) Email
Storage Chembase ID: 133732


IUPAC name
tetralithium(1+) ion hydrate {[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphonato}oxy)phosphinato]amino}phosphonate
IUPAC Traditional name
tetralithium(1+) ion hydrate ({[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphonato}oxyphosphinato)aminophosphonate
β,γ-Imidoadenosine 5′-triphosphate lithium salt hydrate
Adenylyl imidodiphosphate lithium salt hydrate


CAS Number 25612-73-1(freeacid)
Beilstein Number 6047109
PubChem SID 24890685


Purity ≥93% (HPLC)
Shipped in dry ice
Apperance white powder
Solubility H2O: soluble50 mg/mL
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Storage Temperature -20°C
German water hazard class 3


Description (English)
Biochem/physiol Actions
A non-hydrolyzable ATP analog. AMP-PNP competitively inhibits ATP-dependent enzyme systems, such as glutamine synthetase. It inhibits a number of enzymes which require the hydrolysis of ATP such as DNA topoisomerase II, SV40 large T-antigen helicase and a number of kinases. Blocks ATP-sensitive calcium-dependent potassium channels.
AMP-PNP is very unstable in acidic conditions; rapidly hydrolyzes to the phosphoramidate and inorganic phosphate.
A 10 mg/mL stock solution may be made, aliquoted and stored at -70 °C for up to 3 months.
Adenosine 5′-(β,γ-imido)triphosphate lithium salt hydrate has been used in a study to research the effects of monovalent cations Li+, Na+, K+, NH4+, Rb+ and Cs+ on the solid and solution structures of the nucleic acid components. Adenosine 5′-(β,γ-imido)triphosphate lithium salt hydrate has also been used in a study to determine that antidepressants inhibit interferon-γ-induced microglial production of IL-6 and nitric oxide.