Benzo[a]pyrene

• Catalog No.: B1760
• CAS Number: 50-32-8
• M. F.: C20H12
• M. W.: 252.30928
• Purity: ≥96% (HPLC)

SYNONYMS

• Title: 苯并[a]芘
• IUPAC name: pentacyclo[10.6.2.0^2,^7.0^9,^1^9.0^1^6,^2^0]icosa-1(18),2(7),3,5,8,10,12,14,16,19-decaene
• IUPAC Traditional name: pentacyclo[10.6.2.0^2,^7.0^9,^1^9.0^1^6,^2^0]icosa-1(18),2(7),3,5,8,10,12,14,16,19-decaene
• Synonyms: 苯并[det]屈; 苯并芘; 3,4-苯并芘

DATABASE IDS

• MDL Number: MFCD00003602
• PubChem SID: 24891610
• CAS Number: 50-32-8
• Beilstein Number: 1911333
• EC Number: 200-028-5

PROPERTIES

• Purity: ≥96% (HPLC)
• Boiling Point: 495 °C(lit.)
• Melting Point: 177-180 °C(lit.)
• GHS Signal Word: Danger
• GHS Hazard statements: H317-H340-H350-H360FD-H410
• European Hazard Symbols: Toxic (T)
• European Hazard Symbols: Nature polluting (N)
• GHS Precautionary statements: P201-P273-P280-P308 + P313-P501
• RID/ADR: UN 3077 9/PG 3
• Risk Statements: 45-46-60-61-43-50/53
• RTECS: DJ3675000
• Safety Statements: 53-45-60-61
• Hazard Class: 9
• UN Number: 3077
• Packing Group: 3
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
A polycyclic aromatic hydrocarbon (PAH), environmental pollutant and carcinogen. Used as a chemical carcinogen in experimental models of cancer. Carcinogenesis depends on it′s oxidation by CYP1A1 to benzo[a]pyrenediolepoxide, that forms depurinating adducts with DNA that dissociate to form abasic lesions. Benzo[a]pyrene is a ligand for the arylhydrocarbon receptor (AhR), and some of its biological effects, including the induction of CYP1A1, appear to be mediated via activation of the AhR.