Acetyl coenzyme A lithium salt

• Catalog No.: A2181
• CAS Number: 32140-51-5
• M. F.: C23H35Li3N7O17P3S
• M. W.: 827.369983
• Purity: ≥93% (HPLC)

SYNONYMS

• Title: 乙酰辅酶 A 三锂盐
• IUPAC name: trilithium(1+) ion (3R)-3-[(2-{[2-(acetylsulfanyl)ethyl]carbamoyl}ethyl)carbamoyl]-3-hydroxy-2,2-dimethylpropyl ({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3-(hydrogen phosphonatooxy)-4-hydroxyoxolan-2-yl]methyl phosphonato}oxy)phosphonate
• IUPAC Traditional name: trilithium(1+) ion (3R)-3-[(2-{[2-(acetylsulfanyl)ethyl]carbamoyl}ethyl)carbamoyl]-3-hydroxy-2,2-dimethylpropyl {[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3-(hydrogen phosphonatooxy)-4-hydroxyoxolan-2-yl]methyl phosphonato}oxyphosphonate
• Synonyms: Acetyl-CoA; 乙酰辅酶 A 三锂盐

DATABASE IDS

• MDL Number: MFCD00167406
• CAS Number: 32140-51-5
• PubChem SID: 24890633

PROPERTIES

• Purity: ≥93% (HPLC)
• Quality Level: PREMIUM
• Gene Information: human ... CHAT(1103), HAT1(8520), KAT2A(2648), KAT2B(8850), KAT5(10524)mouse ... HAT1(107435), KAT2A(14534), KAT2B(18519), KAT5(81601)rat ... HAT1(296501), KAT2A(303539), KAT2B(301164), KAT5(192218)
• GHS Signal Word: Warning
• GHS Hazard statements: H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P261-P305 + P351 + P338
• Risk Statements: 36/37/38
• Safety Statements: 26-36/37
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (简体中文)

Application
An essential cofactor in enzymatic acetyl transfer reactions.
Biochem/physiol Actions
在酶催化乙酰基转移反应中，乙酰辅酶 A 是必要的辅因子和酰基载体。它可以通过线粒体中丙酮酸的氧化脱羧反应，或者长链脂肪酸的氧化反应，或者某些氨基酸的氧化降解反应而形成。它是脂质生物合成的重要前体以及所有脂肪酸的碳源。它是丙酮酸羧化酶的正调节物。它是神经递质乙酰胆碱的前体。
Other Notes
For more more technical information and a complete list of Coenzyme A deriviatives visit the Acyl Transfer Reagents Resource.
Preparation Note
酶法制备
Reconstitution
Acetyl CoA is soluble in deionized water at 100 mg/mL. Acetyl CoA is stable in neutral and moderately acidic solutions but will hydrolyze in alkaline and strongly acidic solutions. Aqueous solutions stored in single-use aliquots are stable for up to two weeks at -20°C and up to 6 months at -80°C.
Physical properties
This moisture-sensitive powder should be stored desiccated at -20°C.