Aurintricarboxylic acid ammonium salt

• Catalog No.: A0885
• CAS Number: 569-58-4
• M. F.: C22H23N3O9
• M. W.: 473.43272

SYNONYMS

• Title: 金精三羧酸 铵盐
• IUPAC name: 5-[(3-carboxy-4-hydroxyphenyl)(3-carboxy-4-oxocyclohexa-2,5-dien-1-ylidene)methyl]-2-hydroxybenzoic acid triamine
• IUPAC Traditional name: aurintricarboxylic acid triamine
• Synonyms: ATA; Aluminon; Ammonium aurintricarboxylate

DATABASE IDS

• Beilstein Number: 3900820
• CAS Number: 569-58-4
• PubChem SID: 24890465
• Color Index Number: 43810
• EC Number: 209-319-1
• MDL Number: MFCD00040925

PROPERTIES

• Apperance: powder
• Melting Point: 220-225 °C (dec.)(lit.)
• GHS Signal Word: Warning
• GHS Hazard statements: H315-H319
• European Hazard Symbols: Irritant (Xi)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P305 + P351 + P338
• Risk Statements: 36/38
• RTECS: GU4800000
• Safety Statements: 26-36
• German water hazard class: 2

DETAILS

Description (简体中文)

Other Notes
May contain a substantial amount of polymeric material.
包装
25 g in glass bottle
Biochem/physiol Actions
Aurintricarboxylic acid readily polymerizes in aqueous solution, forming a stable free radical that inhibits protein-nucleic acid interactions1. It is a potent inhibitor of ribonuclease1 and topoisomerase II2 by preventing the binding of the nucleic acid to the enzyme. It stimulates tyrosine phosphorylation processes including the Jak2/STAT5 pathway in NB2 lymphoma cells3, ErbB4 in neuroblastoma cells4, and MAP kinases, Shc proteins, phosphatidylinositide 3-kinase and phospholipase C in PC12 cells5. Aurintricarboxylic acid inhibits apoptosis in many cell types. Its neuroprotective effect, perhaps due to its ability to prevent down-regulation of Ca2+ impermeable GluR2 receptors6 or to its ability to inhibit calpain, a Ca2+-activated protease that is activated during apoptosis7.