Somatostatin

• Catalog No.: S0885
• CAS Number: 38916-34-6
• M. F.: C76H104N18O19S2
• M. W.: 1637.87816

SYNONYMS

• Title: 生长抑素
• IUPAC name: (4R,10S,13S,16S,19S,22S,25S,28S,31S,34S,37R)-19,34-bis(4-aminobutyl)-37-{2-[(2S)-2-aminopropanamido]acetamido}-13,25,28-tribenzyl-31-(carbamoylmethyl)-10,16-bis[(1R)-1-hydroxyethyl]-7-(hydroxymethyl)-22-(1H-indol-3-ylmethyl)-6,9,12,15,18,21,24,27,30,33,36-undecaoxo-1,2-dithia-5,8,11,14,17,20,23,26,29,32,35-undecaazacyclooctatriacontane-4-carboxylic acid
• IUPAC Traditional name: (4R,10S,13S,16S,19S,22S,25S,28S,31S,34S,37R)-19,34-bis(4-aminobutyl)-37-{2-[(2S)-2-aminopropanamido]acetamido}-13,25,28-tribenzyl-31-(carbamoylmethyl)-10,16-bis[(1R)-1-hydroxyethyl]-7-(hydroxymethyl)-22-(1H-indol-3-ylmethyl)-6,9,12,15,18,21,24,27,30,33,36-undecaoxo-1,2-dithia-5,8,11,14,17,20,23,26,29,32,35-undecaazacyclooctatriacontane-4-carboxylic acid
• Synonyms: 生长抑素-14; 促生长素释放抑制因子; SRIF; 生长激素释放抑制因子

DATABASE IDS

• MDL Number: MFCD00076762
• EC Number: 254-186-5
• PubChem SID: 24899450
• Beilstein Number: 6436064
• CAS Number: 38916-34-6

PROPERTIES

• Potency: 0.3-50 ng/mL
• Sterility: γ-irradiated
• Suitability: suitable for cell culture
• Gene Information: human ... SSTR1(6751), SSTR2(6752), SSTR3(6753), SSTR4(6754), SSTR5(6755)
• Apperance: powder
• Solubility: cell culture medium: soluble10 mL/vial
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• RTECS: WF8751700
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (简体中文)

Amino Acid Sequence
Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys
Biochem/physiol Actions
Somatostatin regulates endocrine function and cell proliferation via interaction with G-protein-coupled somatostatin receptors. It exists in two active forms produced by alternative cleavage of a single preproprotein (14 aa and 28 aa forms). Somatosatin inhibits the release of growth hormone; thyroid-stimulating hormone and a range of gastrointestinal hormones: Cholecystokinin (CCK); Enteroglucagon; Gastrin; Gastric inhibitory polypeptide (GIP); Motilin; Secretin; Vasoactive intestinal peptide (VIP).
Reconstitution
加入 10mL 无菌培养基可制成 2μg/mL 的储存液。
Physical form
0°C 下为粉末状；分成小份冻存，以避免使用时重复冰冻/解冻