Sinefungin

• Catalog No.: S8559
• CAS Number: 58944-73-3
• M. F.: C15H23N7O5
• M. W.: 381.38702
• Purity: 95% (HPLC)

SYNONYMS

• IUPAC name: (2S,5S)-2,5-diamino-6-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]hexanoic acid
• IUPAC Traditional name: sinefungin
• Synonyms: A-9145; Antibiotic 32232RP; 5′-Deoxy-5′-(1,4-diamino-4-carboxybutyl)adenosine; Adenosylornithine

DATABASE IDS

• PubChem SID: 24899800
• CAS Number: 58944-73-3

PROPERTIES

• Purity: 95% (HPLC)
• Apperance: white to yellow powder
• Solubility: H2O: soluble
• GHS Signal Word: Warning
• GHS Hazard statements: H302
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• Risk Statements: 22
• RTECS: HE3140000
• Safety Statements: 36
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Sinefungin blocks the methylation of bases in DNA and RNA, such as 5-methylcytosine or N6-methyladenosine, suggesting a role in gene expression. In addition, sinefugin is involved in physiological processes such as aging and carcinogenesis.
Sinefungin blocks the methylation of bases in DNA and RNA, such as 5-methylcytosine or N6-methyladenosine, suggesting a role in gene expression. In addition, sinefugin is involved in physiological processes such as aging and carcinogenesis.Methylation inhibition by sinefugin is often accompanied by an altered rate of cytosine deamination that is coupled to transition mutation in the DNA. Sinefugin inhibits Epstein-Barr viral activity and this inhibition is related to the change in DNA methylation and gene expression. It can cause a rate change in several restriction DNA endonuclease activities, including Mme I, which is not connected to the inhibition of the methytransferase activity.