S-(5′-Adenosyl)-L-methionine p-toluenesulfonate salt

• Catalog No.: A2408
• CAS Number: 17176-17-9
• M. F.: C22H30N6O8S2
• M. W.: 570.639
• Purity: ≥80% (HPLC)

SYNONYMS

• IUPAC name: [(3S)-3-amino-3-carboxypropyl]({[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl})methylsulfanium 4-methylbenzene-1-sulfonate
• IUPAC Traditional name: SAMe tosylate
• Synonyms: AdoMet; SAM p-toluenesulfonate salt

DATABASE IDS

• CAS Number: 17176-17-9
• MDL Number: MFCD00063498
• PubChem SID: 24890653

PROPERTIES

• Biological Source: from yeast (L-methionine enriched)
• Compostion: p-Toluenesulfonate content, 1.6-4.4 mol/mol
• Purity: ≥80% (HPLC)
• Purity: ≥80% (spectrophotometric assay)
• Shipped in: dry ice
• Solubility: H2O: soluble100 mg/mL
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
S-(5′-Adenosyl)-L-methionine (SAM) is anti-apoptotic in normal hepatocytes and normal colon epithelial cells but pro-apoptotic in liver human hepatocellular carcinoma (HCC), HepG2 cells and colon cancer cells.
Methyl donor; cofactor for enzyme-catalyzed methylations, including catechol O-methyltransferase (COMT) and DNA methyltransferases (DNMT). Although present in all cells, it is concentrated in liver where 85% of all methylation reactions occur. It is also involved in regulating liver function, growth, and response to injury.
Caution
This material is unstable at room temperature.