[des-Gly10, D-His(Bzl)6]-LH-RH ethylamide

• Catalog No.: L2761
• CAS Number: 76712-82-8
• M. F.: C66H86N18O12
• M. W.: 1323.50244
• Purity: ≥97% (HPLC)

SYNONYMS

• IUPAC name: 1-(2-{2-[3-(1-benzyl-1H-imidazol-4-yl)-2-[2-(3-hydroxy-2-{2-[3-(1H-imidazol-5-yl)-2-[(5-oxopyrrolidin-2-yl)formamido]propanamido]-3-(1H-indol-3-yl)propanamido}propanamido)-3-(4-hydroxyphenyl)propanamido]propanamido]-4-methylpentanamido}-5-carbamimidamidopentanoyl)-N-ethylpyrrolidine-2-carboxamide
• IUPAC Traditional name: 1-(2-{2-[3-(1-benzylimidazol-4-yl)-2-[2-(3-hydroxy-2-{2-[3-(3H-imidazol-4-yl)-2-[(5-oxopyrrolidin-2-yl)formamido]propanamido]-3-(1H-indol-3-yl)propanamido}propanamido)-3-(4-hydroxyphenyl)propanamido]propanamido]-4-methylpentanamido}-5-carbamimidamidopentanoyl)-N-ethylpyrrolidine-2-carboxamide
• Synonyms: Histrelin

DATABASE IDS

• PubChem SID: 24896325
• MDL Number: MFCD00133494
• CAS Number: 76712-82-8

PROPERTIES

• Compostion: Peptide content, ~70%
• Purity: ≥97% (HPLC)
• Gene Information: human ... GNRH1(2796), GNRHR(2798)mouse ... GNRH1(14714), GNRHR(14715)rat ... GNRH1(25194), GNRHR(81668)
• Apperance: powder
• GHS Signal Word: Danger
• GHS Hazard statements: H360
• European Hazard Symbols: Toxic (T)
• Personal Protective Equipment: Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS Precautionary statements: P201-P308 + P313
• Risk Statements: 60
• RTECS: OK6370800
• Safety Statements: 53-22-36/37/39-45
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (English)

Amino Acid Sequence
Glp-His-Trp-Ser-Tyr-His(Bzl)-Leu-Arg-Pro-NHEt
Biochem/physiol Actions
Potent LH-RH agonist; inhibits actions of sex steroids on the male and female reproductive organs.
Features and Benefits
Has greater lipophilicity than other LH-RH agonists, but retains high water solubility