3,3′-Methylene-bis(4-hydroxycoumarin)

• Catalog No.: M1390
• CAS Number: 66-76-2
• M. F.: C19H12O6
• M. W.: 336.29498

SYNONYMS

• IUPAC name: 4-hydroxy-3-[(4-hydroxy-2-oxo-2H-chromen-3-yl)methyl]-2H-chromen-2-one
• IUPAC Traditional name: dicoumarol
• Synonyms: Dicoumarol; Dicumarol

DATABASE IDS

• PubChem SID: 24896643
• MDL Number: MFCD00006857
• EC Number: 200-632-9
• CAS Number: 66-76-2

PROPERTIES

• Gene Information: human ... CYP2C9(1559)
• Melting Point: 290-292 °C(lit.)
• GHS Signal Word: Danger
• GHS Hazard statements: H302-H372-H411
• European Hazard Symbols: Toxic (T)
• European Hazard Symbols: Nature polluting (N)
• Personal Protective Equipment: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
• GHS Precautionary statements: P273-P314
• RID/ADR: UN 2811 6.1/PG 3
• Risk Statements: 22-48/25-51/53
• RTECS: GN7875000
• Safety Statements: 37-45-61
• Hazard Class: 6.1
• UN Number: 2811
• Packing Group: 3
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Prototype of the 4-hydroxycoumarin class of anticoagulants, which act as vitamin K antagonists, preventing formation of prothrombin. There are many reports that dicumarol also inhibits NADPH:quinone oxidoreductase (NQO(1)). In one1, it inhibited NQO(1) in a pancreatic cancer cell line, causing increased formation of superoxide and inhibiting cell growth.